Design of a study assessing disease behaviour during the peri-diagnostic period in patients with interstitial lung disease: The STARLINER study

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dc.contributor.author Wijsenbeek, Marlies
dc.contributor.author Bendstrup, Elisabeth
dc.contributor.author Valenzuela, Claudia
dc.contributor.author Henry, Michael T.
dc.contributor.author Moor, Catharina
dc.contributor.author Bengus, Monica
dc.contributor.author Perjesi, Andras
dc.contributor.author Gilberg, Frank
dc.contributor.author Kirchgaessler, Klaus-Uwe
dc.contributor.author Vancheri, Carlo
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.contributor.other Instituto de Investigación del Hospital de La Princesa (IP) es_ES
dc.date.accessioned 2020-09-09T10:27:01Z
dc.date.available 2020-09-09T10:27:01Z
dc.date.issued 2019-11-30
dc.identifier.citation Advances in Therapy 36.1 (2019): 232–243 en_US
dc.identifier.issn 0741-238X (print) es_ES
dc.identifier.issn 1865-8652 (online) es_ES
dc.identifier.uri http://hdl.handle.net/10486/691816
dc.description.abstract Background/Objectives: This study will aim to characterise disease behaviour during the peridiagnostic period in patients with suspected interstitial lung disease (ILD), including idiopathic pulmonary fibrosis (IPF), using daily home spirometry and accelerometry. Additionally, this study will aim to increase collaboration between secondary and tertiary centres using a digital collaboration platform. Methods: The STARLINER study (NCT03261037) will enrol approximately 180 symptomatic patients aged 50 years or more with radiological evidence of ILD/IPF from community and tertiary centres in Canada and Europe. Approximately two-thirds of sites will be community centres. Patients will be followed during prediagnosis (inclusion to diagnosis; up to a maximum of 12 months) and post-diagnosis (diagnosis to treatment initiation; up to a maximum of 6 months). The study will be facilitated by a digital ecosystem consisting of the devices used for home-based assessments and a digital collaboration platform enabling communication between community and tertiary centres, and between clinicians and patients. Planned Outcomes: The primary endpoint will be time-adjusted semi-annual change in forced vital capacity (FVC; in millilitres) during the peri-diagnostic period. Physical functional capacity and patient-reported outcomes (PROs) will also be assessed. FVC and physical functional capacity will be measured using daily home spirometry and accelerometry, and at site visits using spirometry and the 6-min walk test. PROs will be assessed prior to, or during, site visits and will always be completed in the same order. Conclusions: Findings from this study may help to facilitate the early and accurate diagnosis of ILDs by increasing knowledge about disease progression, enabling collaboration between community and tertiary centres and improving communication between clinicians and patients en_US
dc.description.sponsorship This study is sponsored by F. Hoffmann-La Roche, Ltd., Basel, Switzerland. en_US
dc.format.extent 12 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en
dc.publisher Springer en_US
dc.relation.ispartof Advances in Therapy en_US
dc.rights © 2018 The Author(s) en_US
dc.subject.other Digital ecosystem en_US
dc.subject.other Disease behaviour en_US
dc.subject.other Home-based assessment en_US
dc.subject.other Idiopathic pulmonary fibrosis en_US
dc.subject.other Interstitial lung disease en_US
dc.subject.other Pulmonary/respiratory en_US
dc.subject.other Virtual multidisciplinary team en_US
dc.title Design of a study assessing disease behaviour during the peri-diagnostic period in patients with interstitial lung disease: The STARLINER study en_US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.1007/s12325-018-0845-3 es_ES
dc.identifier.doi 10.1007/s12325-018-0845-3 es_ES
dc.identifier.publicationfirstpage 232 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage 243 es_ES
dc.identifier.publicationvolume 36 es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento – NoComercial es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Valenzuela, Claudia (325130)


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