Myoinvasive pattern as a prognostic marker in low-grade, early-stage endometrioid endometrial carcinoma
Entidad
UAM. Departamento de Anatomía PatológicaEditor
MDPI, Basel, SwitzerlandFecha de edición
2019-11-22Cita
10.3390/cancers11121845
Cancers 11 (2019): 1845
ISSN
2072-6694DOI
10.3390/cancers11121845Financiado por
This research was funded by the Instituto de Salud Carlos III (ISCIII) (PI17/01723), co-financed by the European Development Regional Fund ‘A way to achieve Europe’ (FEDER).Proyecto
Gobierno de España. PI17/01723Versión del editor
https://doi.org/10.3390/cancers11121845Materias
Endometrial carcinoma; Myoinvasive pattern; Prognosis; Microsatellite instability; Mismatch repair protein; Early stage; MedicinaDerechos
© 2019 by the authors. Licensee MDPI, Basel, SwitzerlandResumen
Low-grade and early Federation for Gynecology and Obstetrics (FIGO) stage endometrioid
endometrial carcinomas (EEC) have an excellent prognosis. However, approximately 10% of patients
develop recurrence, which cannot be correctly predicted at diagnosis. We evaluated myoinvasive
patterns as a prognostic factor of relapse in low-grade, early-stage EEC. Two-hundred and fifty-eight
cases were selected according to the following inclusion criteria: (i) endometrioid endometrial
carcinomas, (ii) grade 1 or 2 with (iii) FIGO stage I or II, and (iv) clinical follow-up. Slides were reviewed
to annotate the myoinvasive pattern present in each case (infiltrative glands, microcystic, elongated
and fragmented –MELF-, broad front, adenomyosis-like and adenoma malignum). Microsatellite
instability was studied by immunoexpression of mismatch repair proteins (MLH1, PMS2, MSH2, and
MSH6). There were 29 recurrences (11.2%) among the 258 cases analysed. A predominant broad front
myoinvasive pattern was significantly associated with tumour relapse (p = 0.003). The presence of a
pattern of infiltrative glands (p = 0.001) and microsatellite instability (p = 0.004) were associated with
lower disease-free survival, without having an impact on overall survival. Our observations suggest
the potential value of the pattern of myoinvasion as a prognostic factor in low-grade, early-stage endometrioid endometrial carcinoma
Lista de ficheros
Google Scholar:Ruz-Caracuel, Ignacio
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Ramón-Patino, Jorge L.
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López-Janeiro, Álvaro
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Yébenes, Laura
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Berjón, Alberto
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Hernández, Alicia
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Gallego, Alejandro
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Heredia-Soto, Victoria
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Mendiola, Marta
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Redondo Sánchez, Andrés
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Peláez-García, Alberto
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Hardisson Hernáez, David Alonso
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