UAM | UAM_Biblioteca | Unified search engine | Scientific Production Portal | UAM Research Data Repository
Biblos-e Archivo
    • español
    • English
  • English 
    • español
    • English
  • Log in
JavaScript is disabled for your browser. Some features of this site may not work without it.

Search Biblos-e Archivo

Advanced Search

Browse

All of Biblos-e ArchivoCommunities & CollectionsBy Issue DateAuthorsTitlesSubjectsFacultiesThis CollectionBy Issue DateAuthorsTitlesSubjectsFaculties

My Account

Log inRegister

Statistics

View Usage Statistics

Help

Information about Biblos-e ArchivoI want to submit my workFrequently Asked Questions

UAM_Biblioteca

View Item 
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item
  •   Biblos-e Archivo
  • 1 - Producción científica en acceso abierto de la UAM
  • Producción científica en acceso abierto de la UAM
  • View Item

Vascular smooth muscle cell-specific progerin expression in a mouse model of Hutchinson–Gilford progeria syndrome promotes arterial stiffness: Therapeutic effect of dietary nitrite

Author
del Campo, Lara; Sánchez-López, Amanda; Salaices Sánchez, Mercedesuntranslated; von Kleeck, Ryan A.; Expósito, Elba; González-Gómez, Cristina; Cussó, Lorena; Guzmán-Martínez, Gabriela; Ruiz-Cabello, Jesús; Desco, Manuel; Assoian, Richard K.; Briones Alonso, Ana Maríauntranslated; Andrés, Vicente
Entity
UAM. Departamento de Farmacología
Publisher
Wiley
Date
2019-03-18
Citation
10.1111/acel.12936
Aging Cell 18.3 (2019): e12936
 
 
 
ISSN
1474-9718
DOI
10.1111/acel.12936
Funded by
This study was supported by the Spanish Ministerio de Ciencia, Innovación y Universidades (MCIU, grants SAF2016‐79490‐R and SAF2016‐80305‐P), with co‐funding from the European Regional Development Fund (ERDF, “Una manera de hacer Europa”). RvK and RKA are supported by NIH grants AG047373, T32‐GM008076, F31HL142160 and NSF grant CMMI 1548571. L.d.C. was supported by a Jordi Soler postdoctoral grant from the Red de Investigación Cardiovascular (RETIC Program, Instituto de Salud Carlos III), and A.S.‐L. was supported by a Severo Ochoa predoctoral grant from the MCIU (SVP‐2014‐068334) and by a grant from Asociación Apadrina la Ciencia‐Ford España‐Ford Motor Company Fund. The CNIC is supported by the MCIU and the Pro‐CNIC Foundation, and is a Severo Ochoa Center of Excellence (SEV‐2015‐0505)
Project
Gobierno de España. SAF2016‐79490‐R; Gobierno de España. SAF2016‐80305‐P
Editor's Version
https://doi.org/10.1111/acel.12936
Subjects
aging; dietary nitrite; progeria; smooth muscle cells; vascular stiffness; Medicina
URI
http://hdl.handle.net/10486/691936
Rights
© 2019 The Authors

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Vascular stiffness is a major cause of cardiovascular disease during normal aging and in Hutchinson–Gilford progeria syndrome (HGPS), a rare genetic disorder caused by ubiquitous progerin expression. This mutant form of lamin A causes premature aging associated with cardiovascular alterations that lead to death at an average age of 14.6 years. We investigated the mechanisms underlying vessel stiffness in LmnaG609G/G609G mice with ubiquitous progerin expression, and tested the effect of treatment with nitrites. We also bred LmnaLCS/LCSTie2Cre+/tgand LmnaLCS/LCSSM22αCre+/tg mice, which express progerin specifically in endothelial cells (ECs) and in vascular smooth muscle cells (VSMCs), respectively, to determine the specific contribution of each cell type to vascular pathology. We found vessel stiffness and inward remodeling in arteries of LmnaG609G/G609G and LmnaLCS/LCSSM22αCre+/tg, but not in those from LmnaLCS/LCSTie2Cre+/tgmice. Structural alterations in aortas of progeroid mice were associated with decreased smooth muscle tissue content, increased collagen deposition, and decreased transverse waving of elastin layers in the media. Functional studies identified collagen (unlike elastin and the cytoskeleton) as an underlying cause of aortic stiffness in progeroid mice. Consistent with this, we found increased deposition of collagens III, IV, V, and XII in the media of progeroid aortas. Vessel stiffness and inward remodeling in progeroid mice were prevented by adding sodium nitrite in drinking water. In conclusion, LmnaG609G/G609G arteries exhibit stiffness and inward remodeling, mainly due to progerin-induced damage to VSMCs, which causes increased deposition of medial collagen and a secondary alteration in elastin structure. Treatment with nitrites prevents vascular stiffness in progeria
Show full item record

Files in this item

Thumbnail
Name
vascular_campos_AC_2019.pdf
Size
1.440Mb
Format
PDF

Refworks Export

Google™ Scholar:del Campo, Lara - Sánchez-López, Amanda - Salaices Sánchez, Mercedes - von Kleeck, Ryan A. - Expósito, Elba - González-Gómez, Cristina - Cussó, Lorena - Guzmán-Martínez, Gabriela - Ruiz-Cabello, Jesús - Desco, Manuel - Assoian, Richard K. - Briones Alonso, Ana María - Andrés, Vicente

This item appears in the following Collection(s)

  • Producción científica en acceso abierto de la UAM [17129]

Related items

Showing items related by title, author, creator and subject.

  • HuR mediates the synergistic effects of angiotensin II and IL-1β on vascular COX-2 expression and cell migration 

    Aguado Gómez, AlfredoAutoridad UAM; Rodríguez, C.; Martínez-Revelles, Sonia; Avendaño, M. S.; Zhenyukh, O.; Orriols, M.; Martínez-González, J.; Alonso, M. J.; Briones Alonso, Ana MaríaAutoridad UAM; Dixon, D. A.; Salaices Sánchez, MercedesAutoridad UAM
    2015-06-01
  • G protein-coupled receptor kinase 2 (GRK2) as a potential therapeutic target in cardiovascular and metabolic diseases 

    Murga Montesinos, CristinaAutoridad UAM; Arcones, Alba C.; Cruces-Sande, Marta; Briones Alonso, Ana MaríaAutoridad UAM; Salaices Sánchez, MercedesAutoridad UAM; Mayor Menéndez, FedericoAutoridad UAM
    2019-02-19
  • Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation 

    Zhenyukh, Olha; González-Amor, Maria; Rodrigues Díez, RaúlAutoridad UAM; Esteban, Vanesa; Ruiz Ortega, MartaAutoridad UAM; Salaices Sánchez, MercedesAutoridad UAM; Mas, Sebastian; Briones Alonso, Ana MaríaAutoridad UAM; Egido, Jesus
    2018-10-01
All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram

Declaración de accesibilidad

 

 

All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
Contact Us | Send Feedback
We are onFacebookCanal BiblosYouTubeTwitterPinterestWhatsappInstagram

Declaración de accesibilidad