Cohort profile: the MCC-Spain follow-up on colorectal, breast and prostate cancers: study design and initial results
Author
Alonso-Molero, Jessica; Molina, Antonio J.; Jiménez-Moleón, José Juan; Pérez-Gómez , Beatriz; Martín, Vicente; Moreno, Víctor; Amiano, Pilar; Ardanaz, Eva; Sanjose, Silvia; Salcedo, Inmaculada; Fernández-Tardón, Guillermo; Alguacil, Juan; Salas, Dolores; Marcos-Gragera, Rafael; Chirlaque, María Dolores; Aragonés, Nuria; Castaño-Vinyals, Gemma; Pollán Santamaría, Marina Anunciación; Kogevinas, Manolis; Llorca, JavierPublisher
BMJ Publishing GroupDate
2019Citation
10.1136/bmjopen-2019-031904
BMJ Open 9 (2019): e031904
ISSN
2044-6055DOI
10.1136/bmjopen-2019-031904Funded by
The study was partially funded by the 'Accion Transversal del Cancer', approved on the Spanish Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533, PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada, PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034, PI18/00181), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (the ICGC CLL-Genome Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009, PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10), by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the Consejería de Sanidad de la Región de Murcia, by the European Commission (grants FOOD-CT- 2006-036224-HIWATE), by the Spanish Association Against Cancer (AECC) Scientific Foundation (GCTRA18022MORE), by the Catalan Government-Agency for Management of University and Research Grants (AGAUR) (grants 2017SGR723 and 2014SGR850), by the Fundación Caja de Ahorros de Asturias, and by the University of Oviedo. ISGlobal is a member of the CERCA Programme, Generalitat de CatalunyaProject
Gobierno de España. PI11/01403; Gobierno de España. PI11/01889-FEDER; Gobierno de España. PI11/00226; Gobierno de España. PI11/01810; Gobierno de España. PI11/02213; Gobierno de España. PI12/00488; Gobierno de España. PI12/00265; Gobierno de España. PI12/01270; Gobierno de España. PI12/00715; Gobierno de España. PI12/00150; Gobierno de España. PI14/01219; Gobierno de España. PI14/0613; Gobierno de España. PI15/00069; Gobierno de España. PI15/00914; Gobierno de España. PI15/01032; Gobierno de España. PI17CIII/00034; Gobierno de España. PI18/00181; Gobierno de España. RD12/0036/0036Editor's Version
https://doi.org/10.1136/ bmjopen-2019-031904Subjects
España; Diagnóstico cáncer; Pacientes con cáncer; Estudio y seguimiento; MedicinaRights
© 2019 Author(s) (or their employer(s))Abstract
Purpose Since 2016, the multicase-control
study in
Spain (MCC-Spain)
has focused towards the identification
of factors associated with cancer prognosis. Inception
cohorts of patients with colorectal, breast and prostate
cancers were assembled using the incident cases
originally recruited.
Participants 2140 new cases of colorectal cancer,
1732 of breast cancer and 1112 of prostate cancer were
initially recruited in 12 Spanish provinces; all cancers
were incident and pathologically confirmed. Follow-up
was
obtained for 2097 (98%), 1685 (97%) and 1055 (94.9%)
patients, respectively.
Findings to date Information gathered at recruitment
included sociodemographic factors, medical history,
lifestyle and environmental exposures. Biological
samples were obtained, and 80% of patients were
genotyped using a commercial exome array. The
follow-up
was performed by (1) reviewing medical
records; (2) interviewing the patients by phone on
quality of life; and (3) verifying vital status and cause
of death in the Spanish National Death Index. Ninety-seven
per cent of recruited patients were successfully
followed up in 2017 or 2018; patient-years
of follow-up
were 30 914. Most colorectal cancers (52%)
were at clinical stage II or lower at recruitment; 819
patients died in the follow-up
and the 5-year
survival
was better for women (74.4%) than men (70.0%). 71%
of breast cancers were diagnosed at stages I or II;
206 women with breast cancer died in the follow-up
and the 5-year
survival was 90.7%. 49% of prostate
cancers were diagnosed at stage II and 32% at stage
III; 119 patients with prostate cancer died in the
follow-up
and the 5-year
survival was 93.7%.
Future plans MCC-Spain
has built three prospective
cohorts on highly frequent cancers across Spain,
allowing to investigate socioeconomic, clinical, lifestyle,
environmental and genetic variables as putative
prognosis factors determining survival of patients of
the three cancers and the inter-relationship
of these factors
Files in this item
Google Scholar:Alonso-Molero, Jessica
-
Molina, Antonio J.
-
Jiménez-Moleón, José Juan
-
Pérez-Gómez , Beatriz
-
Martín, Vicente
-
Moreno, Víctor
-
Amiano, Pilar
-
Ardanaz, Eva
-
Sanjose, Silvia
-
Salcedo, Inmaculada
-
Fernández-Tardón, Guillermo
-
Alguacil, Juan
-
Salas, Dolores
-
Marcos-Gragera, Rafael
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Chirlaque, María Dolores
-
Aragonés, Nuria
-
Castaño-Vinyals, Gemma
-
Pollán Santamaría, Marina Anunciación
-
Kogevinas, Manolis
-
Llorca, Javier
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