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Emerging roles of lysyl oxidases in the cardiovascular system: New concepts and therapeutic challenges

Author
Martínez-González, José; Varona, Saray; Cañes, Laia; Galán, María; Briones Alonso, Ana Maríauntranslated; Cachofeiro, Victoria; Rodríguez, Cristina
Entity
UAM. Departamento de Farmacología; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
Publisher
MDPI, Basel, Switzerland
Date
2019-10-14
Citation
10.3390/biom9100610
Biomolecules 9.10 (2019): 610
 
 
 
ISSN
2218-273X
DOI
10.3390/biom9100610
Funded by
The authors thank the support provided by the Spanish Ministerio de Ciencia, Innovación y Universidades (MICIU), Instituto de Salud Carlos III (ISCIII) [grants RTI2018-094727-B-100, PI18/0919,] and Agencia de Gestio d’Ajuts Universitaris i de Recerca (AGAUR; program of Support to Research Groups, Ref. 2017-SGR-00333). Our studies were also co-founded by Fondo Europeo de Desarrollo Regional (FEDER), a way to make Europe. L.C. and M.G. were supported by a FI fellowship (AGAUR) and the Miguel de Servet Program (ISCIII; CP15/00126) respectively
Project
Gobierno de España. RTI2018-094727-B-100; Gobierno de España. PI18/0919
Editor's Version
https://doi.org/10.3390/biom9100610
Subjects
Lsyl oxidases; Cardiovascular diseases; Atherosclerosis; Aortic aneurysm; Vascular calcificationen; Vascular stiffness; Myocardial fibrosis; Farmacia
URI
http://hdl.handle.net/10486/692021
Rights
© 2019 by the authors. Licensee MDPI, Basel, Switzerland

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Lysyl oxidases (LOX and LOX-likes (LOXLs) isoenzymes) belong to a family of copper-dependent enzymes classically involved in the covalent cross-linking of collagen and elastin, a pivotal process that ensures extracellular matrix (ECM) stability and provides the tensile and elastic characteristics of connective tissues. Besides this structural role, in the last years, novel biological properties have been attributed to these enzymes, which can critically influence cardiovascular function. LOX and LOXLs control cell proliferation, migration, adhesion, di erentiation, oxidative stress, and transcriptional regulation and, thereby, their dysregulation has been linked to a myriad of cardiovascular pathologies. Lysyl oxidase could modulate virtually all stages of the atherosclerotic process, from endothelial dysfunction and plaque progression to calcification and rupture of advanced and complicated plaques, and contributes to vascular sti ness in hypertension. The alteration of LOX/LOXLs expression underlies the development of other vascular pathologies characterized by a destructive remodeling of the ECM, such as aneurysm and artery dissections, and contributes to the adverse myocardial remodeling and dysfunction in hypertension, myocardial infarction, and obesity. This review examines the most recent advances in the study of LOX and LOXLs biology and their pathophysiological role in cardiovascular diseases with special emphasis on their potential as therapeutic targets
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Google™ Scholar:Martínez-González, José - Varona, Saray - Cañes, Laia - Galán, María - Briones Alonso, Ana María - Cachofeiro, Victoria - Rodríguez, Cristina

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  • Producción científica en acceso abierto de la UAM [16522]

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All the documents from Biblos-e Archivo are protected by copyrights. Some rights reserved.
Universidad Autónoma de Madrid. Biblioteca
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