Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
A guide to applying the sex-gender perspective to nutritional genomics
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y MicrobiologíaPublisher
MDPI, Basel, SwitzerlandDate
2018-12-20Citation
10.3390/nu11010004
Nutrients 11.4 (2019): 1-22
ISSN
2072-6643DOI
10.3390/nu11010004Funded by
This study was partially funded by the Spanish Ministry of Health (Instituto de Salud Carlos III) and the Ministerio de Economía y Competitividad-Fondo Europeo de Desarrollo Regional (FEDER) (grants CIBER 06/03, PRX17/00500, PI16/00366, PI06/1326, and SAF2016–80532-R); the University Jaume I (grants P1–1B2013–54 and COGRUP/2016/06); the Fundació La Marató de TV3 (grant 538/U/2016); the Real Colegio Complutense at Harvard University, the Generalitat Valenciana (grant PROMETEO2017/017 and AEST/2018/044) and by the US Department of Agriculture, Agriculture Research Service (8050–51000-098-00D)Project
Gobierno de España. PRX17/00500; Gobierno de España. PI16/00366; Gobierno de España. PI06/1326; Gobierno de España. SAF2016–80532-REditor's Version
https://doi.org/10.3390/nu11010004Subjects
Sex; Gender; Diet; Nutritional genomics; Nutrigenomics; Precision nutrition; MedicinaRights
© 2018 by the authorsAbstract
Precision nutrition aims to make dietary recommendations of a more personalized nature
possible, to optimize the prevention or delay of a disease and to improve health. Therefore,
the characteristics (including sex) of an individual have to be taken into account as well as a series
of omics markers. The results of nutritional genomics studies are crucial to generate the evidence
needed so that precision nutrition can be applied. Although sex is one of the fundamental variables
for making recommendations, at present, the nutritional genomics studies undertaken have not
analyzed, systematically and with a gender perspective, the heterogeneity/homogeneity in gene-diet
interactions on the different phenotypes studied, thus there is little information available on this
issue and needs to be improved. Here we argue for the need to incorporate the gender perspective
in nutritional genomics studies, present the general context, analyze the differences between sex
and gender, as well as the limitations to measuring them and to detecting specific sex-gene or
sex-phenotype associations, both at the specific gene level or in genome-wide-association studies.
We analyzed the main sex-specific gene-diet interactions published to date and their main limitations
and present guidelines with recommendations to be followed when undertaking new nutritional genomics studies incorporating the gender perspective
Files in this item
Google Scholar:Corella, Dolores
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Coltell, Óscar
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Portolés, Olga
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Sotos-Prieto, Mercedes
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Fernández-Carrión, Rebeca
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Ramírez-Sabio, Judith B.
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Zanón-Moreno, Vicente
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Mattei, Josiemer
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Sorlí, José V.
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Ordovas, José M.
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