DPP4 and ACE2 in diabetes and COVID-19: Therapeutic targets for cardiovascular complications?

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dc.contributor.author Valencia, Inés
dc.contributor.author Peiró, Concepción
dc.contributor.author Lorenzo, Óscar
dc.contributor.author Sánchez-Ferrer, Carlos F.
dc.contributor.author Eckel, Jürgen
dc.contributor.author Romacho, Tania
dc.contributor.other UAM. Departamento de Farmacología es_ES
dc.contributor.other UAM. Departamento de Medicina es_ES
dc.date.accessioned 2020-10-27T14:34:46Z
dc.date.available 2020-10-27T14:34:46Z
dc.date.issued 2020-08-07
dc.identifier.citation Frontiers in Pharmacology 11 (2020): 1161 en_US
dc.identifier.issn 1663-9812 es_ES
dc.identifier.uri http://hdl.handle.net/10486/692332
dc.description.abstract COVID-19 outbreak, caused by severe acute respiratory syndrome (SARS)-CoV-2 coronavirus has become an urgent health and economic challenge. Diabetes is a risk factor for severity and mortality of COVID-19. Recent studies support that COVID-19 has effects beyond the respiratory tract, with vascular complications arising as relevant factors worsening its prognosis, then making patients with previous vascular disease more prone to severity or fatal outcome. Angiotensin-II converting enzime-2 (ACE2) has been proposed as preferred receptor for SARS-CoV-2 host infection, yet specific proteins participating in the virus entry are not fully known. SARS-CoV-2 might use other co-receptor or auxiliary proteins allowing virus infection. In silico experiments proposed that SARS-CoV-2 might bind dipeptidyl peptidase 4 (DPP4/CD26), which was established previously as receptor for MERS-CoV. The renin–angiotensin–aldosterone system (RAAS) component ACE2 and DPP4 are proteins dysregulated in diabetes. Imbalance of the RAAS and direct effect of soluble DPP4 exert deleterious vascular effects. We hypothesize that diabetic patients might be more affected by COVID-19 due to increased presence ACE2 and DPP4 mediating infection and contributing to a compromised vasculature. Here, we discuss the role of ACE2 and DPP4 as relevant factors linking the risk of SARS-CoV-2 infection and severity of COVID-19 in diabetic patients and present an outlook on therapeutic potential of current drugs targeted against RAAS and DPP4 to treat or prevent COVID-19-derived vascular complications. Diabetes affects more than 400 million people worldwide, thus better understanding of how they are affected by COVID-19 holds an important benefit to fight against this disease with pandemic proportions en_US
dc.description.sponsorship IV is the recipient of a FPU fellowship (FPU16/02612). TR and JE are supported by KomIT-Center of Competence for Innovative Diabetes Therapy- funded by EFRE-NRW. CP and CS-F are supported by a grant from Plan Nacional de I+D (SAF2017-84776-R) en_US
dc.format.extent 14 pag. es_ES
dc.format.mimetype application/pdf es_ES
dc.language.iso eng es_ES
dc.publisher Frontiers Media en_US
dc.relation.ispartof Frontiers in Pharmacology en_US
dc.rights Copyright © 2020 Valencia, Peiro, Lorenzo, Sánchez-Ferrer, Eckel and Romacho en_US
dc.subject.other ACEi es_ES
dc.subject.other angiotensin converting enzyme 2 en_US
dc.subject.other cardiovascular disease en_US
dc.subject.other COVID-19 en_US
dc.subject.other diabetes es_ES
dc.subject.other dipeptidyl peptidase 4 en_US
dc.subject.other gliptins en_US
dc.subject.other SARS-CoV-2 en_US
dc.title DPP4 and ACE2 in diabetes and COVID-19: Therapeutic targets for cardiovascular complications? en_US
dc.type article en_US
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion https://doi.org/10.3389/fphar.2020.01161 es_ES
dc.identifier.doi 10.3389/fphar.2020.01161 es_ES
dc.identifier.publicationfirstpage 1161-1 es_ES
dc.identifier.publicationissue 11 es_ES
dc.identifier.publicationlastpage 1161-14 es_ES
dc.relation.projectID Gobierno de España. SAF2017-84776-R es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess es_ES
dc.authorUAM Valencia Fernández, Inés (281299)
dc.authorUAM Peiró Vallejo, M. Concepción (259003)
dc.authorUAM Lorenzo González, Oscar (261806)
dc.authorUAM Sánchez Ferrer, Carlos Félix (259402)

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