dc.contributor.author | Ayuso-Álvarez, Ana | |
dc.contributor.author | García-Pérez, Javier | |
dc.contributor.author | Triviño-Juárez, José-Matías | |
dc.contributor.author | Larrinaga-Torrontegui, Unai | |
dc.contributor.author | González-Sánchez, Mario | |
dc.contributor.author | Ramis, Rebeca | |
dc.contributor.author | Boldo, Elena | |
dc.contributor.author | López-Abente, Gonzalo | |
dc.contributor.author | Galán Labaca, Ignacio | |
dc.contributor.author | Fernández-Navarro, Pablo | |
dc.contributor.author | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | es_ES |
dc.contributor.other | UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología | es_ES |
dc.date.accessioned | 2020-11-25T14:06:21Z | |
dc.date.available | 2020-11-25T14:06:21Z | |
dc.date.issued | 2020-01-03 | |
dc.identifier.citation | Environmental Pollution 260. May (2020): 113869 | en_US |
dc.identifier.issn | 0269-7491 (print) | es_ES |
dc.identifier.issn | 1873-6424 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/692542 | |
dc.description.abstract | It is likely that pollution from chemical facilities will affect the health of any exposed population;
however, the majority of scientific evidence available has focused on occupational exposure rather than
environmental. Consequently, this study assessed whether there could have been an excess of cancerrelated
mortality associated with environmental exposure to pollution from chemical installations e
for populations residing in municipalities in the vicinity of chemical industries. To this end, we designed
an ecological study which assessed municipal mortality due to 32 types of cancer in the period from 1999
to 2008. The exposure to pollution was estimated using distance from the facilities to the centroid of the
municipality as a proxy for exposure. In order to assess any increased cancer mortality risk in municipalities
potentially exposed to chemical facilities pollution (situated at a distance of 5 km from a
chemical installation), we employed Bayesian Hierarchical Poisson Regression Models. This included two
Bayesian inference methods: Integrated Nested Laplace Approximations (INLA) and Markov Chain Monte
Carlo (MCMC, for validation). The reference category consisted of municipalities beyond the 5 km limit.
We found higher mortality risk (relative risk, RR; estimated by INLA, 95% credible interval, 95%CrI) for
both sexes for colorectal (RR, 1.09; 95%CrI, 1.05e1.15), gallbladder (1.14; 1.03e1.27), and ovarian cancers
(1.10; 1.02e1.20) associated with organic chemical installations. Notably, pleural cancer (2.27; 1.49e3.41)
in both sexes was related to fertilizer facilities. Associations were found for women, specifically for
ovarian (1.11; 1.01e1.22) and breast cancers (1.06; 1.00e1.13) in the proximity of explosives/pyrotechnics
installations; increased breast cancer mortality risk (1.10; 1.03e1.18) was associated with proximity to
inorganic chemical installations. The results suggest that environmental exposure to pollutants from
some types of chemical facilities may be associated with increased mortality from several different types of cancer | en_US |
dc.description.sponsorship | The study was partially supported by research grants from the Spanish Health Research
Fund, Carlos III Institute of Health (ISCIII), Spain (FIS CP11/00112, FIS
PI14CIII/00065, FIS PI17CIII/00040) and by Scientific Foundation of
the Spanish Association Against Cancer (AECC), Spain (Fundación
Científica de la Asociación Española Contra el Cáncer (AECC) e EVP-1178/14) | en_US |
dc.format.extent | 11 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ltd | en_US |
dc.relation.ispartof | Environmental Pollution | en_US |
dc.rights | © 2020 The Authors | en_US |
dc.subject.other | Polution | en_US |
dc.subject.other | Chemical indistry | en_US |
dc.subject.other | Health | en_US |
dc.subject.other | Environmental | en_US |
dc.subject.other | Cancer | en_US |
dc.title | Association between proximity to industrial chemical installations and cancer mortality in Spain | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.envpol.2019.113869 | es_ES |
dc.identifier.doi | 10.1016/j.envpol.2019.113869 | es_ES |
dc.identifier.publicationfirstpage | 113869-1 | es_ES |
dc.identifier.publicationissue | May | en_US |
dc.identifier.publicationlastpage | 113869-11 | es_ES |
dc.identifier.publicationvolume | 260 | es_ES |
dc.relation.projectID | Gobierno de España. FIS CP11/00112 | es_ES |
dc.relation.projectID | Gobierno de España. FIS PI14CIII/00065 | es_ES |
dc.relation.projectID | Gobierno de España. FIS PI17CIII/00040) | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento – NoComercial – SinObraDerivada | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Ayuso Álvarez, Ana (262194) | |
dc.authorUAM | Galán Labaca, Ignacio (262111) | |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | |