Beneficial effect of a multistrain synbiotic prodefen® plus on the systemic and vascular alterations associated with metabolic syndrome in rats: The role of the neuronal nitric oxide synthase and protein kinase A

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dc.contributor.author Llévenes, Pablo
dc.contributor.author Rodrigues-Díez, Raquel
dc.contributor.author Cros-Brunsó, Laia
dc.contributor.author Prieto, Mª Isabel
dc.contributor.author Casani, Laura
dc.contributor.author Balfagón, Gloria
dc.contributor.author Blanco-Rivero, Javier
dc.contributor.other UAM. Departamento de Cirugía es_ES
dc.contributor.other UAM. Departamento de Farmacología es_ES
dc.contributor.other UAM. Departamento de Fisiología es_ES
dc.contributor.other Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) es_ES
dc.date.accessioned 2020-11-26T07:47:31Z
dc.date.available 2020-11-26T07:47:31Z
dc.date.issued 2020-01-01
dc.identifier.citation Nutrients 12.1 (2020): 117 en_US
dc.identifier.issn 2072-6643 es_ES
dc.identifier.uri http://hdl.handle.net/10486/692568
dc.description.abstract A high fat diet (HFD) intake is crucial for the development and progression of metabolic syndrome (MtS). Increasing evidence links gut dysbiosis with the metabolic and vascular alterations associated with MtS. Here we studied the use of a combination of various probiotic strains together with a prebiotic (synbiotic) in a commercially available Prodefen® Plus. MtS was induced by HFD (45%) in maleWistar rats. Half of the MtS animals received Prodefen® Plus for 4 weeks. At 12 weeks, we observed an increase in body weight, together with the presence of insulin resistance, liver steatosis, hypertriglyceridemia and hypertension in MtS rats. Prodefen® Plus supplementation did not a ect the body weight gain but ameliorated all the MtS-related symptoms. Moreover, the hypertension induced by HFD is caused by a diminished both nitric oxide (NO) functional role and release probably due to a diminished neuronal nitric oxide synthase (nNOS) activation by protein kinase A (PKA) pathway. Prodefen® Plus supplementation for 4 weeks recovered the NO function and release and the systolic blood pressure was returned to normotensive values as a result. Overall, supplementation with Prodefen® Plus could be considered an interesting non-pharmacological approach in MtS. en_US
dc.description.sponsorship This research was funded by Italfarmaco, S.A (L.O.U. 83; 0138/2018), CiberCV (Grant number: CB16/11/00286), the European Regional Development Grant (FEDER) (Comunidad de Madrid, Grant number B2017/BMD-3676), and R + D projects for young researchers, Universidad Autónoma de Madrid (Comunidad de Madrid (SI1-PJI-2019-00321). R.R.-D. received a fellowship from Juan de la Cierva Program (IJCI-2017-31399). en_US
dc.format.extent 18 pag. es_ES
dc.format.mimetype application/pdf en
dc.language.iso eng en_US
dc.publisher MDPI, Basel, Switzerland en_US
dc.relation.ispartof Nutrients en_US
dc.rights © 2020 The Authors en_US
dc.subject.other Metabolic syndrome es_ES
dc.subject.other Synbiotic es_ES
dc.subject.other Hypertension es_ES
dc.subject.other Mesenteric artery es_ES
dc.subject.other Perivascular nitrergic innervation es_ES
dc.subject.other Nitric oxide es_ES
dc.subject.other Neuronal nitric oxide synthase es_ES
dc.subject.other Protein kinase a es_ES
dc.title Beneficial effect of a multistrain synbiotic prodefen® plus on the systemic and vascular alterations associated with metabolic syndrome in rats: The role of the neuronal nitric oxide synthase and protein kinase A en:US
dc.type article en
dc.subject.eciencia Medicina es_ES
dc.relation.publisherversion http://doi.org/doi:10.3390/nu12010117 es_ES
dc.identifier.doi 10.3390/nu12010117 es_ES
dc.identifier.publicationfirstpage 117-1 es_ES
dc.identifier.publicationissue 1 es_ES
dc.identifier.publicationlastpage 117-18 es_ES
dc.identifier.publicationvolume 12 es_ES
dc.relation.projectID Comunidad de Madrid. B2017/BMD-3676/AORTASANA es_ES
dc.type.version info:eu-repo/semantics/publishedVersion en
dc.rights.cc Reconocimiento es_ES
dc.rights.accessRights openAccess en
dc.authorUAM Balfagón Calvo, Gloria (259549)
dc.authorUAM Blanco Rivero, Javier (260695)
dc.authorUAM Prieto Nieto, María Isabel (261977)
dc.authorUAM Rodrigues Díez, Raquel (324127) es_ES


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