Overfeeding during lactation in rats is associated with cardiovascular insulin resistance in the short-term
EntityUAM. Departamento de Fisiología
10.3390/nu12020549Nutrients 12.2 (2020): 549
Funded byThis study has been funded by the grant to Precompetitive Projects of Universidad San Pablo CEU and Banco Santander 2016, and by a grant from the Community of Madrid (CAM) awarded to Daniel González-Hedström (IND2017/BIO7701, Spain)
ProjectComunidad de Madrid. IND2017/BIO-7701
SubjectsCardiovascular; Childhood obesity; Early overnutrition; Insulin; Lactation; Rat; Medicina
Rights© 2020 by the authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Childhood obesity is associated with metabolic and cardiovascular comorbidities. The development of these alterations may have its origin in early life stages such as the lactation period through metabolic programming. Insulin resistance is a common complication in obese patients and may be responsible for the cardiovascular alterations associated with this condition. This study analyzed the development of cardiovascular insulin resistance in a rat model of childhood overweight induced by overfeeding during the lactation period. On birth day, litters were divided into twelve (L12) or three pups per mother (L3). Overfed rats showed a lower increase in myocardial contractility in response to insulin perfusion and a reduced insulin-induced vasodilation, suggesting a state of cardiovascular insulin resistance. Vascular insulin resistance was due to decreased activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, whereas cardiac insulin resistance was associated with mitogen-activated protein kinase (MAPK) hyperactivity. Early overfeeding was also associated with a proinflammatory and pro-oxidant state; endothelial dysfunction; decreased release of nitrites and nitrates; and decreased gene expression of insulin receptor (IR), glucose transporter-4 (GLUT-4), and endothelial nitric oxide synthase (eNOS) in response to insulin. In conclusion, overweight induced by lactational overnutrition in rat pups is associated with cardiovascular insulin resistance that could be related to the cardiovascular alterations associated with this condition
Google Scholar:González-Hedström, Daniel - Guerra-Menéndez, Lucía - Tejera-Muñoz, Antonio - Amor, Sara - de la Fuente-Fernández, María - Martín-Carro, Beatriz - Arriazu, Riansares - García-Villalón, Ángel Luis - Granado, Miriam
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