Supplementation with a carob (Ceratonia siliqua l.) fruit extract attenuates the cardiometabolic alterations associated with metabolic syndrome in mice
AuthorDe La Fuente-Fernández, María; González-Hedström, Daniel; Amor, Sara; Tejera-Muñoz, Antonio; Fernández Monsalve, Nuria; Monge Sánchez, Luis; Almodóvar, Paula; Andrés Delgado, Laura; Santamaría Solís, Luis; Prodanov Prodanov, Marin; Inarejos-García, Antonio Manuel; García-Villalón, Angel Luis; Granado García, Miriam
EntityUAM. Departamento de Anatomía, Histología y Neurociencia; UAM. Departamento de Fisiología; UAM. Departamento de Química Física Aplicada
PublisherMDPI, Basel, SMwitzerland
10.3390/antiox9040339Antioxidants 9.4 (2020): 339
Funded byThis work has been funded by Pharmactive Biotech Products S.L. and by Grants from Community of Madrid awarded to Daniel González-Hedström (IND2017/BIO7701,) and María de la Fuente-Fernández (PEJ-2018-AI/SAL-11315)
SubjectsAnti-inflammatory; Antioxidant; Cardiovascular; Carob; Coronary ischemia; Endothelial dysfunction; Insulin resistance; Metabolic syndrome; Medicina
Rights© 2020 The Authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
The incidence of metabolic syndrome (MetS) is increasing worldwide which makes necessary the finding of new strategies to treat and/or prevent it. The aim of this study was to analyze the possible beneficial effects of a carob fruit extract (CSAT+®) on the cardiometabolic alterations associated with MetS in mice. 16-week-old C57BL/6J male mice were fed for 26 weeks either with a standard diet (chow) or with a diet rich in fats and sugars (HFHS), supplemented or not with 4.8% of CSAT+®. CSAT+® supplementation reduced blood glucose, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) and circulating levels of total cholesterol, low-density lipoprotein (LDL) cholesterol (LDL-c), insulin, and interleukin-6 (IL-6). In adipose tissue and skeletal muscle, CSAT+® prevented MetS-induced insulin resistance, reduced macrophage infiltration and the expression of pro-inflammatory markers, and up-regulated the mRNA levels of antioxidant markers. Supplementation with CSAT+® prevented MetS-induced hypertension and decreased the vascular response of aortic rings to angiotensin II (AngII). Moreover, treatment with CSAT+® attenuated endothelial dysfunction and increased vascular sensitivity to insulin. In the heart, CSAT+® supplementation reduced cardiomyocyte apoptosis and prevented ischemia-reperfusion-induced decrease in cardiac contractility. The beneficial effects at the cardiovascular level were associated with a lower expression of pro-inflammatory and pro-oxidant markers in aortic and cardiac tissues.
Google Scholar:De La Fuente-Fernández, María - González-Hedström, Daniel - Amor, Sara - Tejera-Muñoz, Antonio - Fernández Monsalve, Nuria - Monge Sánchez, Luis - Almodóvar, Paula - Andrés Delgado, Laura - Santamaría Solís, Luis - Prodanov Prodanov, Marin - Inarejos-García, Antonio Manuel - García-Villalón, Angel Luis - Granado García, Miriam
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