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Tumour characteristics and survivorship in a cohort of breast cancer: the MCC-Spain study

Author
Gómez-Acebo, Inés; Dierssen-Sotos, Trinidad; Palazuelos-Calderón, Camilo; Pérez-Gómez, Beatriz; Amiano, Pilar; Guevara, Marcela; Molina, Antonio J.; Domingo, Laia; Fernández-Ortiz, María; Moreno, Victor; Alguacil, Juan; Fernández-Tardón, Guillermo; Ibáñez, Josefa; Marcos-Gragera, Rafael; Diaz-Santos, Marian; Alonso, M. Henar; Alonso-Molero, Jessica; Castaño-Vinyals, Gemma; García Palomo, Andrés; Ardanaz, Eva; Molinuevo, Amaia; Aragonés, Nuria; Kogevinas, Manolis; Pollán, Marina; Llorca, Javier
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología
Publisher
Springer Nature
Date
2020-06-01
Citation
10.1007/s10549-020-05600-x
Breast Cancer Research and Treatment 181.3 (2020): 667-678
 
 
 
ISSN
0167-6806; 1573-7217 (online)
DOI
10.1007/s10549-020-05600-x
Funded by
This work was supported by the ‘Acción Transversal del Cancer’, approved by the Spanish Ministry Council on the 11th October 2007, by the Instituto de Salud Carlos III, co-founded by FEDER funds – ‘a way to build Europe’ (grants PI08/1770, PI08/0533, PI08/1359, PI09/00773, PI09/01286, PI09/01903, PI09/02078, PI09/01662, PI11/01403, PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715, PI12/00150, PI14/01219, PI14/00613 and PI15/00069). Support was also provided by the Fundación Marqués de Valdecilla (grant API 10/09); the Junta de Castilla y León (grant LE22A10-2); the Consejería de Salud of the Junta de Andalucía (2009-S0143); the Conselleria de Sanitat of the Generalitat Valenciana (grant AP 061/10); the Recercaixa (grant 2010ACUP 00310); the Regional Government of the Basque Country; the Consejería de Sanidad de la Región de Murcia; European Commission grants FOOD-CT-2006–036224-HIWATE; the Spanish Association Against Cancer (AECC) Scientific Foundation; the Catalan Government DURSI (grant 2014SGR647); the Fundación Caja de Ahorros de Asturias; the University of Oviedo; Societat Catalana de Digestologia; and COST action BM1206 Eucolongene
Project
Gobierno de España. PI08/1770; Gobierno de España. PI08/0533; Gobierno de España. PI08/1359; Gobierno de España. PI09/00773; Gobierno de España. PI09/01286,; Gobierno de España. PI09/01903; Gobierno de España. PI09/02078; Gobierno de España. PI09/01662; Gobierno de España. PI11/01403,; Gobierno de España. PI11/01889; Gobierno de España. PI11/00226; Gobierno de España. PI11/01810; Gobierno de España. PI11/02213; Gobierno de España. PI12/00488; Gobierno de España. PI12/00265; Gobierno de España. PI12/01270; Gobierno de España. PI12/00715; Gobierno de España. PI12/00150; Gobierno de España. PI14/01219; Gobierno de España. PI14/00613; Gobierno de España. d PI15/00069
Editor's Version
http://doi.org/10.1007/s10549-020-05600-x
Subjects
Breast cancer; Cohort; Epidemiology; MCC-spain; Relative survival; Medicina
URI
http://hdl.handle.net/10486/693667
Rights
© 2020 The Authors

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

Purpose: The objective of this study is to analyse the relative survival with breast cancer in women diagnosed after new treatments were generalised and to ascertain the current effect that tumour characteristics such as grade, stage or subtype have on survival as well as the new AJCC-pathological prognostic score. Methods: The breast cancer MCC-Spain follow-up study is a prospective cohort study of 1685 incident breast cancer cases. Women between 20 and 85 years old were recruited between the years 2008 and 2013 in 18 hospitals located in 10 Spanish provinces and they have been followed until 2017/2018. Relative survival was estimated after 3, 5 and 8 years of follow-up using Ederer II method. In addition, Weibull regression adjusted by age, hospital, grade and stage was used to investigate prognosis factors. Results: Among components of TNM staging system, tumour size greater than 50 mm (i.e. T3 or T4) more than doubled the risk of dying, while N3 nodal involvement and presence of metastasis had a huge effect on mortality. The AJCC pathological prognostic score strongly correlated with survival; thus, hazard ratios increased as the score rose, being 2.31, 4.00, 4.94, 7.92, 2.26, 14.9 and 58.9 for scores IB, IIA, IIB, IIIA, IIIB, IIIC and IV, respectively. Conclusion: Both TNM staging and histological/molecular biomarkers are associated with overall survival in Spanish women with breast cancer; when both are combined in the AJCC pathological prognosis score, the prognostic value improved with risk indices that increased rapidly as the pathological prognosis score increased
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Google™ Scholar:Gómez-Acebo, Inés - Dierssen-Sotos, Trinidad - Palazuelos-Calderón, Camilo - Pérez-Gómez, Beatriz - Amiano, Pilar - Guevara, Marcela - Molina, Antonio J. - Domingo, Laia - Fernández-Ortiz, María - Moreno, Victor - Alguacil, Juan - Fernández-Tardón, Guillermo - Ibáñez, Josefa - Marcos-Gragera, Rafael - Diaz-Santos, Marian - Alonso, M. Henar - Alonso-Molero, Jessica - Castaño-Vinyals, Gemma - García Palomo, Andrés - Ardanaz, Eva - Molinuevo, Amaia - Aragonés, Nuria - Kogevinas, Manolis - Pollán, Marina - Llorca, Javier

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  • Producción científica en acceso abierto de la UAM [14677]

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