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Mutations in TRIM63 cause an autosomal-recessive form of hypertrophic cardiomyopathy

Author
Salazar-Mendiguchiá, Joel; Ochoa, Juan Pablo; Palomino-Doza, Julian; Domínguez, Fernando; Diéz-López, Carles; Akhtar, Mohammed; Ramiro-León, Soraya; Clemente, Mariá M.; Pérez-Cejas, Antonia; Robledo, Mariá; Gómez-Diáz, Iria; Peña-Peña, Mariá Luisa; Climent, Vicente; Salmerón-Martínez, Francisco; Hernández, Celestino; Garciá-Granja, Pablo E.; Mogollón, M. Victoria; Cárdenas-Reyes, Ivonne; Cicerchia, Marcos; Garciá-Giustiniani, Diego; Lamounier, Arsonval; Gil-Fournier, Belén; Diáz-Flores, Felícitas; Salguero, Rafael; Santomé, Luis; Syrris, Petros; Olivé, Montse; Garciá-Paviá, Pablo; Ortiz-Genga, Martín; Elliott, Perry M.; Monserrat, Lorenzo; Behalf of GENESCOPIC Research Group
Entity
UAM. Departamento de Medicina
Publisher
BMJ
Date
2020-09-01
Citation
10.1136/heartjnl-2020-316913
Heart 106.17 (2020):1342-1348
 
 
 
ISSN
1355-6037 (print); 1468-201X (online)
DOI
10.1136/heartjnl-2020-316913
Funded by
St. Bartholomew’s Hospital (Drs P M Elliot and M Akhtar) and Hospital Universitario Puerta de Hierro Majadahonda (Drs P Garcia-Pavia and F Domínguez) are members of the European Reference Network on Rare and Complex Diseases of the Heart (Guard-Heart; http:// guard- heart. ernnet. eu)
Editor's Version
http://doi.org/10.1136/heartjnl-2020-316913
Subjects
familial cardiomyopathies; genetics; hypertrophic cardiomyopathy; Medicina
URI
http://hdl.handle.net/10486/694170
Rights
© 2020 Author(s) (or their employer(s))

Licencia de Creative Commons
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.

Abstract

Objective Up to 50% of patients with hypertrophic cardiomyopathy (HCM) show no disease-causing variants in genetic studies. TRIM63 has been suggested as a candidate gene for the development of cardiomyopathies, although evidence for a causative role in HCM is limited. We sought to investigate the relationship between rare variants in TRIM63 and the development of HCM. Methods TRIM63 was sequenced by next generation sequencing in 4867 index cases with a clinical diagnosis of HCM and in 3628 probands with other cardiomyopathies. Additionally, 3136 index cases with familial cardiovascular diseases other than cardiomyopathy (mainly channelopathies and aortic diseases) were used as controls. Results Sixteen index cases with rare homozygous or compound heterozygous variants in TRIM63 (15 HCM and one restrictive cardiomyopathy) were included. No homozygous or compound heterozygous were identified in the control population. Familial evaluation showed that only homozygous and compound heterozygous had signs of disease, whereas all heterozygous family members were healthy. The mean age at diagnosis was 35 years (range 15-69). Fifty per cent of patients had concentric left ventricular hypertrophy (LVH) and 45% were asymptomatic at the moment of the first examination. Significant degrees of late gadolinium enhancement were detected in 80% of affected individuals, and 20% of patients had left ventricular (LV) systolic dysfunction. Fifty per cent had non-sustained ventricular tachycardia. Twenty per cent of patients suffered an adverse cerebrovascular event (20%). Conclusion TRIM63 appears to be an uncommon cause of HCM inherited in an autosomal-recessive manner and associated with concentric LVH and a high rate of LV dysfunction.
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Google™ Scholar:Salazar-Mendiguchiá, Joel - Ochoa, Juan Pablo - Palomino-Doza, Julian - Domínguez, Fernando - Diéz-López, Carles - Akhtar, Mohammed - Ramiro-León, Soraya - Clemente, Mariá M. - Pérez-Cejas, Antonia - Robledo, Mariá - Gómez-Diáz, Iria - Peña-Peña, Mariá Luisa - Climent, Vicente - Salmerón-Martínez, Francisco - Hernández, Celestino - Garciá-Granja, Pablo E. - Mogollón, M. Victoria - Cárdenas-Reyes, Ivonne - Cicerchia, Marcos - Garciá-Giustiniani, Diego - Lamounier, Arsonval - Gil-Fournier, Belén - Diáz-Flores, Felícitas - Salguero, Rafael - Santomé, Luis - Syrris, Petros - Olivé, Montse - Garciá-Paviá, Pablo - Ortiz-Genga, Martín - Elliott, Perry M. - Monserrat, Lorenzo - Behalf of GENESCOPIC Research Group

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  • Producción científica en acceso abierto de la UAM [15094]

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