Neurorestoration approach by biomaterials in ischemic stroke
Entity
UAM. Departamento de Psicología Biológica y de la SaludPublisher
Frontiers MediaDate
2020-05-12Citation
10.3389/fnins.2020.00431
Frontiers in Neuroscience 14.May. (2020): 431
ISSN
1662-4548DOI
10.3389/fnins.2020.00431Funded by
We gratefully acknowledge funding from Institute Carlos III (EC11-121) which support our research using biohybrids in the treatment of ischemic stroke. NE-G is funded by a contract from the European Social Fund through the Operational Youth Guarantee Program of the Ministry of Science, Universities and Innovation of the Community of Madrid (PEJD-2019- PRE/BMD-15396). CN was funded by Boston ScientificProject
Gobierno de España. EC11-121Editor's Version
https://doi.org/10.3389/fnins.2020.00431Subjects
biomaterials; cell therapy; neurorestoration; repair; stroke; PsicologíaRights
© 2020 Esteban-Garcia, Nombela, Garrosa, Rascón-Ramirez, Barcia and Sánchez-Sánchez-RojasAbstract
Ischemic stroke (IS) is the leading cause of disability in the western world, assuming a high socio-economic cost. One of the most used strategies in the last decade has been biomaterials, which have been initially used with a structural support function. They have been perfected, different compounds have been combined, and they have been used together with cell therapy or controlled release chemical compounds. This double function has driven them as potential candidates for the chronic treatment of IS. In fact, the most developed are in different phases of clinical trial. In this review, we will show the ischemic scenario and address the most important criteria to achieve a successful neuroreparation from the point of view of biomaterials. The spontaneous processes that are activated and how to enhance them is one of the keys that contribute to the success of the therapeutic approach. In addition, the different routes of administration and how they affect the design of biomaterials are analyzed. Future perspectives show where this broad scientific field is heading, which advances every day with the help of technology and advanced therapies.
Files in this item
Google Scholar:Esteban-Garcia, Noelia
-
Nombela Otero, Cristina
-
Garrosa, Javier
-
Rascón-Ramirez, Fernando J.
-
Barcia, Juan Antonio
-
Sánchez-Sánchez-Rojas, Leyre
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Alberta Stroke Program Early CT Score applied to CT angiography source images is a strong predictor of futile recanalization in acute ischemic stroke
Kawiorski, Michal M.; Martínez-Sánchez, Patricia; García-Pastor, Andrés; Calleja, Patricia; Fuentes Gimeno, Blanca Eulalia; Sanz-Cuesta, Borja E.; Lourido, Daniel; Marín, Begoña; Díaz-Otero, Fernando; Vicente, Agustina; Sierra-Hidalgo, Fernando; Ruiz-Ares, Gerardo; Díez Tejedor, Exuperio; Fandiño, Eduardo; Alonso de Leciñana, María
2016-05-01 -
Glycemic variability: prognostic impact on acute ischemic stroke and the impact of corrective treatment for hyperglycemia. The GLIAS-III translational study
Fuentes Gimeno, Blanca Eulalia; Pastor-Yborra, Silvia; Gutiérrez-Zúñiga, Raquel; González Pérez de Villar, Noemí; de Celis, Elena; Rodríguez-Pardo, Jorge; Gómez-de Frutos, Mari Carmen; Laso-García, Fernando; Gutiérrez-Fernández, María; Ortega-Casarrubios, MÁngeles; Soto, Alfonso; López-Fernández, María; Santamaría, María; Díez-González, Noemí; Freijo, Mar M.; Zandio, Beatriz; Delgado-Mederos, Raquel; Calleja, Ana; Portilla-Cuenca, Juan Carlos; Lisbona, Arturo; Otero-Ortega, Laura; Díez Tejedor, Exuperio
2020-12-01