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Total area of spontaneous portosystemic shunts independently predicts hepatic encephalopathy and mortality in liver cirrhosis

Author
Praktiknjo, Michael; Simón-Talero, Macarena; Römer, Julia; Roccarina, Davide; Martínez, Javier; Lampichler, Katharina; Baiges, Anna; Low, Gavin; Llop, Elba; Maurer, Martin H.; Zipprich, Alexander; Triolo, Michela; Maleux, Geert; Fialla, Annette Dam; Dam, Claus; Vidal-González, Judit; Majumdar, Avik; Picón, Carmen; Toth, Daniel; Darnell, Anna; Abraldes, Juan G.; López, Marta; Jansen, Christian; Chang, Johannes; Schierwagen, Robert; Uschner, Frank; Kukuk, Guido; Meyer, Carsten; Thomas, Daniel; Wolter, Karsten; Strassburg, Christian P.; Laleman, Wim; La Mura, Vincenzo; Ripoll, Cristina; Berzigotti, Annalisa; Calleja, José Luis; Tandon, Puneeta; Hernandez-Gea, Virginia; Reiberger, Thomas; Albillos, Agustín; Tsochatzis, Emmanuel A.; Krag, Aleksander; Genescà, Joan; Trebicka, Jonel; Quiroga, Sergi; Yu, Dominic; Téllez, Luis; Mandorfer, Mattias; Garcia-Pagan, Juan Carlos; Berbel, Claudia; Ferrusquia, José; Ble, Michel; Garcia-Criado, Mari Angeles; Belmonte, Ernest; Ney, Michael; Margini, Cristina; Casu, Stefania; Murgia, Giuseppe; Ludwig, Christiane; Stangl, Franz
Entity
UAM. Departamento de Medicina
Publisher
European Association for the Study of the Liver
Date
2020-06-01
Citation
10.1016/j.jhep.2019.12.021
Journal of Hepatology 72.6 (2020): 1140-1150
 
 
 
ISSN
0168-8278
DOI
10.1016/j.jhep.2019.12.021
Funded by
Jonel Trebicka is supported by grants from the Deutsche Forschungsgemeinschaft (SFB TRR57, CRC1382), Cellex Foundation and European Union’s Horizon 2020 research and innovation program GALAXY study (No. 668031), LIVERHOPE (No. 731875) and MICROB-PREDICT (No. 825694) and the Cellex Foundation. Joan Genescà is a recipient of a Research Intensification grant from Instituto de Salud Carlos III, Spain. The study was partially funded by grants PI15/00066, and PI18/00947 from Instituto de Salud Carlos III and co-funded by European Union (ERDF/ESF, “Investing in your future”). Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivasis supported by Instituto de Salud Carlos III. Macarena Simón-Talero is a recipient of the grant JR 17/00029 from Instituto de Salud Carlos III
Project
Gobierno de España. PI15/00066; Gobierno de España. PI18/00947
Editor's Version
http://doi.org/10.1016/j.jhep.2019.12.021
Subjects
ACLF; Acute decompensation; Acute-on-chronic liver failure; Ascites; Cirrhosis; Computed tomography; Hepatic encephalopathy; Liveren_US; Portal hypertension; Spontaneous portosystemic shunt; SPSS; TIPS; Medicina
URI
http://hdl.handle.net/10486/694244
Rights
© 2020 European Association for the Study of the Liver

Licencia de Creative Commons
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.

Abstract

Background & Aims: Spontaneous portosystemic shunts (SPSS) frequently develop in liver cirrhosis. Recent data suggested that the presence of a single large SPSS is associated with complications, especially overt hepatic encephalopathy (oHE). However, the presence of >1 SPSS is common. This study evaluates the impact of total cross-sectional SPSS area (TSA) on outcomes in patients with liver cirrhosis. Methods: In this retrospective international multicentric study, CT scans of 908 cirrhotic patients with SPSS were evaluated for TSA. Clinical and laboratory data were recorded. Each detected SPSS radius was measured and TSA calculated. One-year survival was the primary endpoint and acute decompensation (oHE, variceal bleeding, ascites) was the secondary endpoint. Results: A total of 301 patients (169 male) were included in the training cohort. Thirty percent of all patients presented with >1 SPSS. A TSA cut-off of 83 mm2 was used to classify patients with small or large TSA (S-/L-TSA). Patients with L-TSA presented with higher model for end-stage liver disease score (11 vs. 14) and more commonly had a history of oHE (12% vs. 21%, p <0.05). During follow-up, patients with L-TSA experienced more oHE episodes (33% vs. 47%, p <0.05) and had lower 1-year survival than those with S-TSA (84% vs. 69%, p <0.001). Multivariate analysis identified L-TSA (hazard ratio 1.66; 95% CI 1.02–2.70, p <0.05) as an independent predictor of mortality. An independent multicentric validation cohort of 607 patients confirmed that patients with L-TSA had lower 1-year survival (77% vs. 64%, p <0.001) and more oHE development (35% vs. 49%, p <0.001) than those with S-TSA. Conclusion: This study suggests that TSA >83 mm2 increases the risk for oHE and mortality in patients with cirrhosis. Our results support the clinical use of TSA/SPSS for risk stratification and decision-making in the management of patients with cirrhosis. Lay summary: The prevalence of spontaneous portosystemic shunts (SPSS) is higher in patients with more advanced chronic liver disease. The presence of more than 1 SPSS is common in advanced chronic liver disease and is associated with the development of hepatic encephalopathy. This study shows that total cross-sectional SPSS area (rather than diameter of the single largest SPSS) predicts survival in patients with advanced chronic liver disease. Our results support the clinical use of total cross-sectional SPSS area for risk stratification and decision-making in the management of SPSS.
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Google™ Scholar:Praktiknjo, Michael - Simón-Talero, Macarena - Römer, Julia - Roccarina, Davide - Martínez, Javier - Lampichler, Katharina - Baiges, Anna - Low, Gavin - Llop, Elba - Maurer, Martin H. - Zipprich, Alexander - Triolo, Michela - Maleux, Geert - Fialla, Annette Dam - Dam, Claus - Vidal-González, Judit - Majumdar, Avik - Picón, Carmen - Toth, Daniel - Darnell, Anna - Abraldes, Juan G. - López, Marta - Jansen, Christian - Chang, Johannes - Schierwagen, Robert - Uschner, Frank - Kukuk, Guido - Meyer, Carsten - Thomas, Daniel - Wolter, Karsten - Strassburg, Christian P. - Laleman, Wim - La Mura, Vincenzo - Ripoll, Cristina - Berzigotti, Annalisa - Calleja, José Luis - Tandon, Puneeta - Hernandez-Gea, Virginia - Reiberger, Thomas - Albillos, Agustín - Tsochatzis, Emmanuel A. - Krag, Aleksander - Genescà, Joan - Trebicka, Jonel - Quiroga, Sergi - Yu, Dominic - Téllez, Luis - Mandorfer, Mattias - Garcia-Pagan, Juan Carlos - Berbel, Claudia - Ferrusquia, José - Ble, Michel - Garcia-Criado, Mari Angeles - Belmonte, Ernest - Ney, Michael - Margini, Cristina - Casu, Stefania - Murgia, Giuseppe - Ludwig, Christiane - Stangl, Franz

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