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Children with type 1 diabetes have elevated high-sensitivity C-reactive protein compared with a control group

Author
Pérez-Segura, Pilar; De Dios, Olaya; Herrero, Leticia; Vales-Villamarín, Claudia; Aragón-Gómez, Isabel; Gavela Pérez, Teresauntranslated; Garcés, Carmen; Soriano Guillén, Leandrountranslated
Entity
UAM. Departamento de Pediatría; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
Publisher
BMJ in partnership with the American Diabetes Association
Date
2020-07-19
Citation
10.1136/bmjdrc-2020-001424
BMJ Open Diabates Research & Care 8.1 (2020): e001424
 
 
 
ISSN
2052-4897
DOI
10.1136/bmjdrc-2020-001424
Funded by
This work was supported by Fundación Familia Alonso
Editor's Version
https://doi.org/10.1136/bmjdrc-2020-001424
Subjects
C-reactive protein; diabetes mellitus, type 1; glycated hemoglobin A; obesity; Medicina
URI
http://hdl.handle.net/10486/694640
Rights
© 2020 Author(s) (or their employer(s))

Licencia de Creative Commons
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.

Abstract

Introduction Our objective was to compare high-sensitivity C-reactive protein (hsCRP) levels in children with type 1 diabetes, healthy controls, and children with obesity. Additionally, we aimed to analyze the association between hsCRP levels and glycemic control measured by glycohemoglobin A (HbA1c) and anthropometric and biochemical variables. Research design and methods We conducted a non-randomized descriptive study of children with type 1 diabetes matched for sex and age with a control group and group with obesity. We recorded anthropometric parameters and studied variables related to diabetes, blood pressure, lipid profile, and HbA1c. hsCRP was measured by ELISA. Results We included 49 children with type 1 diabetes, 46 controls, and 40 children with obesity. hsCRP levels were significantly higher in the group with type 1 diabetes compared with controls and nearly significantly lower than in the group comprising children with obesity. We found no correlation between hsCRP and HbA1c and characteristics of type 1 diabetes with the exception of albumin to creatinine ratio. Statistically significant association was found between hsCRP and body mass index (BMI) and waist circumference Z-score. Conclusions The higher hsCRP levels observed in children with type 1 diabetes compared with a control group with a similar BMI suggest a basal inflammatory state that could increase cardiovascular risk. The main factors related to hsCRP are BMI and waist circumference, so obesity prevention should be a priority when performing follow-up in children with type 1 diabetes.
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Google™ Scholar:Pérez-Segura, Pilar - De Dios, Olaya - Herrero, Leticia - Vales-Villamarín, Claudia - Aragón-Gómez, Isabel - Gavela Pérez, Teresa - Garcés, Carmen - Soriano Guillén, Leandro

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  • Producción científica en acceso abierto de la UAM [18125]

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