Inflammation in Parkinson's disease: Mechanisms and therapeutic implications
Entity
UAM. Departamento de Bioquímica; Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM); Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
MDPI, Basel, SwitzerlandDate
2020-07-14Citation
10.3390/cells9071687
Cells 9.7 (2020):1687
ISSN
2073-4409DOI
10.3390/cells9071687Funded by
This work was supported by PID2019-110061RB-I00 and SAF2017-82436R of the Spanish Ministry of Economy and Competiveness; P-024-FTPGB 2018 from the Spanish “Tatiana de Guzman el Bueno Foundation” and by the P_37_732/2016 grant (REDBRAIN) financed by the European Regional Development Fund, Competitiveness Operational Program 2014–2020. Comunidad Autónoma de Madrid (grants B2017/BMD-3827, S2017-BMD-3686). MP is recipient of a contract Juan de la Cierva (MICINN).Project
Gobierno de España. PID2019-110061RB-I00; Gobierno de España. SAF2017-82436R; Comunidad de Madrid. B2017/BMD-3827/NRF24AD; Comunidad de Madrid. S2017-BMD-3686/CIFRA2Editor's Version
https://doi.org/10.3390/cells9071687Subjects
immune system; neurodegeneration; neuroinflammation; Parkinson’s disease; therapy; MedicinaRights
© 2020 The authorsAbstract
Parkinson's disease (PD) is a common neurodegenerative disorder primarily characterized by the death of dopaminergic neurons that project from the substantia nigra pars compacta. Although the molecular bases for PD development are still little defined, extensive evidence from human samples and animal models support the involvement of inflammation in onset or progression. However, the exact trigger for this response remains unclear. Here, we provide a systematic review of the cellular mediators, i.e., microglia, astroglia and endothelial cells. We also discuss the genetic and transcriptional control of inflammation in PD and the immunomodulatory role of dopamine and reactive oxygen species. Finally, we summarize the preclinical and clinical approaches targeting neuroinflammation in PD.
Files in this item
Google Scholar:Pajares, Marta
-
Rojo Sanchís, Ana Isabel
-
Manda, Gina
-
Boscá, Lisardo
-
Cuadrado Pastor, Antonio
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Transcription factor NRF2 as a therapeutic target for chronic diseases: A systems medicine approach
Cuadrado Pastor, Antonio; Manda, Gina; Hassan, Ahmed; Alcaraz, María José; Barbas, Coral; Daiber, Andreas; Ghezzi, Pietro; León, Rafael; López, Manuela G.; Oliva, Baldo; Pajares, Marta; Rojo Sanchís, Ana Isabel
; Robledinos-Antón, Natalia; Valverde, Ángela M.; Guney, Emre; Schmidt, Harald H.H.W.
2018-04-01