MicroRNAs in rectal cancer: Functional significance and promising therapeutic value
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
MDPI, Basel, SwitzerlandDate
2020-07-24Citation
10.3390/cancers12082040
Cancers 12.8 (2020): 2040
ISSN
2072-6694DOI
10.3390/cancers12082040Funded by
This research was funded by PI18/00382 and PI16/01468 grants from “Instituto de Salud Carlos III FEDER”.Project
Gobierno de España. PI18/00382; Gobierno de España. PI16/01468Editor's Version
https://doi.org/10.3390/cancers12082040Subjects
MicroRNA; Rectal cancer; Signaling; Therapy; MedicinaRights
© 2020 The authors.Abstract
It is well-known that microRNAs (miRNAs) are critical mediators of initiation and disease progression in many human cancers. Rectal cancer is a highly prevalent tumor, accounting for around one third of newly diagnosed colorectal cancers. The usefulness of miRNAs as clinical biomarkers predictive of the outcome and response to chemoradiotherapy has been well-reported for rectal cancer. However, the existing literature on their functional and therapeutic impact needs to be put in context to clarify their role in disease pathogenesis. Therfore, this review is focused on the functional relevance of miRNAs as key regulators of signaling pathways in rectal cancer and their potential therapeutic value as novel molecular targets in this disease.
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Google Scholar:Imedio, Laura
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Cristóbal, Ion
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Rubio, Jaime
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Santos, Andrea
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Rojo, Federico
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García-Foncillas López, Jesús Miguel
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