Gender, albuminuria and chronic kidney disease progression in treated diabetic kidney disease
EntityUAM. Departamento de Farmacología; UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
PublisherMDPI, Basel, SMwitzerland
10.3390/jcm9061611Journal of Clinical Medicine 9.6 (2020): 1611
Funded byThis work and the APC was funded by FIS grant numbers CP14/00133, PI16/02057, PI18/01366, PI19/00588, PI19/00815, DTS18/00032, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN AC18/00071, National Institute of Health (2R01AI063331), ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER, FRIAT, Sociedad Española de Nefrología, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM, Miguel Servet MS14/00133 to M.D.S.-N. and A.B.S. and Cátedra Mundipharma UAM. IIS-Fundacion Jimenez Diaz Biobank, part of the Spanish Biobanks Platform (PT17/0015/0006).
ProjectGobierno de España. CP14/00133; Gobierno de España. PI16/02057; Gobierno de España. PI18/01366; Gobierno de España. PI19/00588; Gobierno de España. PI19/00815; Gobierno de España. DTS18/00032; info:eu-repo/grantAgreement/EC/H2020/779282/EU//ERA; Gobierno de España. RD016/0009; Comunidad de Madrid. B2017/BMD-3686/CIFRA2
Subjectsdiabetic kidney disease; diabetic nephropathy; gender; outcomes; albuminuria; glomerular filtration rate; mortality; Farmacia
Rights© 2020 The Authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Background: Women are reported to have a lower incidence of renal replacement therapy, despite a higher prevalence of chronic kidney disease (CKD). Aim: To analyze diabetic kidney disease (DKD) progression in men and women. Methods: Prospective cohort: n = 261, 35% women, new consecutive nephrology DKD referrals. Results: Women smoked less and better complied with the dietary phosphate and sodium restrictions. Despite a less frequent nephrology referral, women had lower baseline albuminuria. Over a 30 + - 10-month follow-up, albuminuria decreased in women and the estimated glomerular filtration rate (eGFR) loss was slower than in men. However, the percentage of rapid progressors was similar in both sexes. The best multivariate model predicting rapid progression in men (area under curve (AUC) = 0.92) and women differed. Albuminuria and fractional excretion of phosphate (FEphosphate) were part of the men multivariable model, but not of women. The AUC for the prediction of rapid progression by albuminuria was higher in men than in women, and the albuminuria cut-off points also differed. In women, there was a higher percentage of rapid progressors who had baseline physiological albuminuria. Conclusions: Female DKD differs from male DKD: albuminuria was milder and better responsive to therapy, the loss of eGFR was slower and the predictors of rapid progression differed from men: albuminuria was a better predictor in men than in women. Lifestyle factors may contribute to the differences
Google Scholar:Fernández-Fernández, Beatriz - Mahillo, Ignacio - Sánchez-Rodríguez, Jinny - Carriazo, Sol - Sanz, Ana B. - Sánchez Niño, María Dolores - Ortiz Arduán, Alberto
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