dc.contributor.author | Fernández-Fernández, Beatriz | |
dc.contributor.author | Mahillo, Ignacio | |
dc.contributor.author | Sánchez-Rodríguez, Jinny | |
dc.contributor.author | Carriazo, Sol | |
dc.contributor.author | Sanz, Ana B. | |
dc.contributor.author | Sánchez Niño, María Dolores | |
dc.contributor.author | Ortiz Arduán, Alberto | |
dc.contributor.other | UAM. Departamento de Farmacología | es_ES |
dc.contributor.other | UAM. Departamento de Medicina | es_ES |
dc.contributor.other | Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD) | es_ES |
dc.date.accessioned | 2021-04-26T09:30:05Z | |
dc.date.available | 2021-04-26T09:30:05Z | |
dc.date.issued | 2020-05-26 | |
dc.identifier.citation | Journal of Clinical Medicine 9.6 (2020): 1611 | en_US |
dc.identifier.issn | 2077-0383 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/694882 | |
dc.description.abstract | Background: Women are reported to have a lower incidence of renal replacement therapy,
despite a higher prevalence of chronic kidney disease (CKD). Aim: To analyze diabetic kidney
disease (DKD) progression in men and women. Methods: Prospective cohort: n = 261, 35% women,
new consecutive nephrology DKD referrals. Results: Women smoked less and better complied
with the dietary phosphate and sodium restrictions. Despite a less frequent nephrology referral,
women had lower baseline albuminuria. Over a 30 + - 10-month follow-up, albuminuria decreased in
women and the estimated glomerular filtration rate (eGFR) loss was slower than in men. However,
the percentage of rapid progressors was similar in both sexes. The best multivariate model predicting
rapid progression in men (area under curve (AUC) = 0.92) and women differed. Albuminuria and
fractional excretion of phosphate (FEphosphate) were part of the men multivariable model, but not of
women. The AUC for the prediction of rapid progression by albuminuria was higher in men than in
women, and the albuminuria cut-off points also differed. In women, there was a higher percentage of
rapid progressors who had baseline physiological albuminuria. Conclusions: Female DKD differs
from male DKD: albuminuria was milder and better responsive to therapy, the loss of eGFR was
slower and the predictors of rapid progression differed from men: albuminuria was a better predictor in men than in women. Lifestyle factors may contribute to the differences | en_US |
dc.description.sponsorship | This work and the APC was funded by FIS grant numbers CP14/00133, PI16/02057, PI18/01366,
PI19/00588, PI19/00815, DTS18/00032, ERA-PerMed-JTC2018 (KIDNEY ATTACK AC18/00064 and PERSTIGAN
AC18/00071, National Institute of Health (2R01AI063331), ISCIII-RETIC REDinREN RD016/0009 Fondos FEDER,
FRIAT, Sociedad Española de Nefrología, Comunidad de Madrid B2017/BMD-3686 CIFRA2-CM, Miguel Servet
MS14/00133 to M.D.S.-N. and A.B.S. and Cátedra Mundipharma UAM. IIS-Fundacion Jimenez Diaz Biobank, part of the Spanish Biobanks Platform (PT17/0015/0006). | en_US |
dc.format.extent | 13 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en_US |
dc.publisher | MDPI, Basel, SMwitzerland | en_US |
dc.relation.ispartof | Journal of Clinical Medicine | en_US |
dc.rights | © 2020 The Authors | en_US |
dc.subject.other | diabetic kidney disease | en_US |
dc.subject.other | diabetic nephropathy | en_US |
dc.subject.other | gender | en_US |
dc.subject.other | outcomes | en_US |
dc.subject.other | albuminuria | en_US |
dc.subject.other | glomerular filtration rate | en_US |
dc.subject.other | mortality | en_US |
dc.title | Gender, albuminuria and chronic kidney disease progression in treated diabetic kidney disease | en_US |
dc.type | article | en |
dc.subject.eciencia | Farmacia | es_ES |
dc.relation.publisherversion | http://doi.org/10.3390/jcm9061611 | es_ES |
dc.identifier.doi | 10.3390/jcm9061611 | es_ES |
dc.identifier.publicationfirstpage | 1611-1 | es_ES |
dc.identifier.publicationissue | 6 | es_ES |
dc.identifier.publicationlastpage | 1611-13 | es_ES |
dc.identifier.publicationvolume | 9 | es_ES |
dc.relation.projectID | Gobierno de España. CP14/00133 | es_ES |
dc.relation.projectID | Gobierno de España. PI16/02057 | es_ES |
dc.relation.projectID | Gobierno de España. PI18/01366 | es_ES |
dc.relation.projectID | Gobierno de España. PI19/00588 | es_ES |
dc.relation.projectID | Gobierno de España. PI19/00815 | es_ES |
dc.relation.projectID | Gobierno de España. DTS18/00032 | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/779282/EU//ERA | es_ES |
dc.relation.projectID | Gobierno de España. RD016/0009 | es_ES |
dc.relation.projectID | Comunidad de Madrid. B2017/BMD-3686/CIFRA2 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Ortiz Arduan, Alberto (261886) | |
dc.authorUAM | Fernández Fernández, Beatriz (330606) | |
dc.authorUAM | Sánchez Niño, María Dolores (330722) | |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD) | |