Four weeks versus six weeks of ampicillin plus ceftriaxone in Enterococcus faecalis native valve endocarditis: A prospective cohort study
Entity
UAM. Departamento de MedicinaPublisher
Public Library of ScienceDate
2020-08-03Citation
10.1371/journal.pone.0237011
PLoS ONE 15.8 (2020): e0237011
ISSN
1932-6203DOI
10.1371/journal.pone.0237011Funded by
This work was supported in part by the “Fondo de Investigaciones Sanitarias” (FIS) grant 17/01251 from the “Instituto de Salud Carlos III”, Madrid, Spain awarded to JMM. JMM received a personal 80:20 research grant from the Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain, during 2017–19. JMP was member of the Endocarditis Team of the Hospital Clinic of Barcelona, Spain when this project was approved by the GAMES Steering Committee.’Project
Gobierno de España. FIS 17/01251Editor's Version
https://doi.org/10.1371/journal.pone.0237011Subjects
Endocarditis; Treatment; Iinternational guidelines; Four-week course; Efficacy; MedicinaRights
© 2020 Ramos-Martínez et al.Abstract
Enterococcus faecalis infective endocarditis (EFIE) is a severe disease of increasing incidence. The objective was to analyze whether the outcome of patients with native valve EFIE (NVEFIE) treated with a short course of ampicillin plus ceftriaxone (4wAC) was similar to patients treated according to international guidelines (6wAC). Between January 2008 and June 2018, 1,978 consecutive patients with definite native valve IE were prospectively included in a national registry. Outcomes of patients with NVEFIE treated with 4wAC were compared to those of patients who received 6wAC. Three hundred and twenty-two patients (16.3%) had NVEFIE. One hundred and eighty-three (56.8%) received AC. Thirty-nine patients (21.3%) were treated with 4wAC for four weeks and 70 patients (38.3%) with 6wAC. There were no differences in age or comorbidity. Patients treated 6wAC presented a longer duration of symptoms before diagnosis (21 days, IQR 7-60 days vs. 7 days, IQR 1-22 days; p = 0.002). Six patients presented perivalvular abscess and all of these received 6wAC. Surgery was performed on 14 patients (35.9%) 4wAC and 34 patients (48.6%) 6wAC (p = 0.201). In-hospital mortality, one-year mortality and relapses among 4wAC and 6wAC patients were 10.3% vs. 11.4% (p = 0.851); 17.9% vs. 21.4% (p = 0.682) and 5.1% vs. 4.3% (p = 0.833), respectively. In conclusion, a four-week course of AC may be considered as an alternative regimen in NVEFIE, notably in patients with shorter duration of symptoms and those without perivalvular abscess. These results support the performance of a randomized clinical trial to evaluate the efficacy of this short regimen.
Files in this item
Google Scholar:Ramos Martínez, Antonio
-
Pericàs, Juan Manuel
-
Fernández-Cruz, Ana
-
Muñoz, Patricia
-
Valerio, Maricela
-
Kestler, Martha
-
Montejo, Miguel
-
Fariñas, M. Carmen
-
Sousa, Dolores
-
Domínguez, Fernando
-
Ojeda-Burgos, Guillermo
-
Plata, Antonio
-
Vidal, Laura
-
Miró, Jose María
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Clinical factors associated with reinfection versus relapse in infective endocarditis: Prospective cohort study
Calderón-Parra, Jorge; Kestler, Martha; Ramos Martínez, Antonio; Bouza, Emilio; Valerio, Maricela; de Alarcón, Arístides; Luque, Rafael; Goenaga, Miguel Ángel; Echeverría, Tomás; Fariñas, Ma Carmen; Pericàs, Juan M.; Ojeda-Burgos, Guillermo; Fernández-Cruz, Ana; Plata, Antonio; Vinuesa, David; Muñoz, Patricia
2021-02-13 -
Consumption of fried foods and risk of coronary heart disease: Spanish cohort of the European Prospective Investigation into Cancer and Nutrition study
Guallar Castillón, María Pilar; Rodríguez Artalejo, Fernando; López García, Esther; León-Muñoz, Luz María; Amiano, Pilar; Ardanaz, Eva; Arriola, Larraitz; Barricarte, Aurelio; Buckland, Genevieve; Chirlaque, María-Dolores; Dorronsoro, Miren; Huerta, José-María; Larrañaga, Nerea; Marín, Pilar; Martínez, Carmen; Molina, Esther; Navarro, Carmen; Quirós, J Ramón; Rodríguez, Laudina; Sánchez, María José; González, Carlos A.; Moreno-Iribas, Conchi
2012-01-24 -
Very high energy gamma-ray observation of the peculiar transient event Swift J1644+57 with the MAGIC telescopes and AGILE
Aleksić, Jelena; Antonelli, Lucio Angelo; Antoranz, Pedro; Asensio, María Carmen; Backes, Michael; Barres De Almeida, Ulisses; Barrio, Juan Abel; Bednarek, Włodek; Berger, Karsten; Bernardini, Elisa; Biland, Adrian; Blanch, Oscar; Böck, Rudolf; Boller, Andrea; Bonnefoy, S.; Bonnoli, Giacomo; Borla Tridon, D.; Carmona, Emiliano; Carosi, Alessandro; Carreto Fidalgo, D.; Colin, Pierre; Contreras, José Luis; Cortina, Juan; Cossio, L.; Covino, Stefano; Da Vela, P.; Dazzi, Francesco; De Angelis, Annalisa; De Caneva, Gessica; De Lotto, Barbara; Delgado, C.; Doert, Marlene; Domínguez, Alberto; Dominis Prester, D.; Doro, Michele; Eisenacher, Dorit; Ferenc, Daniel; Fruck, C.; García López, Ramón J.; Garczarczyk, Markus; Garrido Terrats, D.; Gaug, Markus; Giavitto, G.; Godinović, N.; González Muñoz, A.; Gozzini, Silvia R.; Hadamek, A.; Hadasch, Daniela; Herrero, Artemio; Hose, Jürgen; Hrupec, Dario; Idec, W.; Jankowski, F.; Kadenius, V.; Klepser, Stefan; Knoetig, M. L.; Krähenbühl, Thomas; Krause, Julian; Kushida, Junko; Lelas, Damir; Lewandowska, N.; Lombardi, Saverio; López, María Luisa Osete; López-Coto, Rubén; López-Oramas, A.; Lorenz, Eckárt; Makariev, M.; Mallot, K.; Mankuzhiyil, Nijil; Mannheim, Karl; Maraschi, Laura; Marcote, B.; Maríotti, Mosé; Martínez, Mario Ivan; Masbou, J.; Mazin, Daniel; Meucci, Mario; Miranda, José Miguel; Mirzoyan, Razmick G.; Moldón, Javier; Moralejo, Abelardo; Munar-Adrover, P.; Nakajima, D.; Niedźwiecki, Andrzej; Nilsson, Kari; Nowak, Nina; Orito, Reiko; Paiano, S.; Palatiello, M.; Paneque, David; Paoletti, Riccardo; Paredes, Josep Maria; Partini, S.; Persic, Massimo; Prada, Francisco; Prada Moroni, Pier Giorgio Prada; Prandini, Elisa; Puljak, Ivica; Reichardt, Ignasi; Reinthal, Riho; Rhode, Wolfgang; Ribó, Marc; Saggion, Antonio; Saito, Koji; Saito, Takayuki; Satalecka, Konstancja; Scalzotto, Villi; Scapin, Valeria; Shore, Steven N.; Sitarek, Julian; Spanier, Felix; Spiro, S.; Stamatescu, Victor; Stamerra, Antonio; Steinke, Burkhard; Storz, J.; Sun, S.; Surić, Tihomir; Takami, Hideki; Tavecchio, Fabrizio; Terzić, Tomislav; Tescaro, Diego; Teshima, Masahiro; Tibolla, Omar; Torres, Diego F.; Toyama, T.; Treves, Aldo; Uellenbeck, Malwina; Vogler, Patrick; Wagner, Robert Marcus; Weitzel, Quirin; Zandanel, Fabio; Zanin, Roberta; Longo, Francesco; Lucarelli, Fabrizio; Pittori, Carlotta; Verrecchia, Francesco; Becerra González, Josefa; Bretz, Thomas; Colombo, Eduardo; Dorner, Daniela; Elsaesser, Dominik; Farina, Emanuele; Fonseca, Maria Victoria; Font, L; La Barbera, Antonio; Lindfors, Elina; Lozano, I; Maneva, Galina; Mirzoyan, Razmick G.; Rico, Javier; Salvati, Marco; Schultz, C; Schweizer, Thomas; Sillanpää, Aimo; Snidaric, I; Sobczynska, Dorota; Takalo, Leo; Temnikov, Petar
2013-04-17