dc.contributor.author | Taddei, Cristina | |
dc.contributor.author | Rodríguez Artalejo, Fernando | |
dc.contributor.author | Banegas Banegas, José Ramón | |
dc.contributor.author | NCD Risk Factor Collaboration (NCD-RisC) | |
dc.contributor.other | UAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología | es_ES |
dc.date.accessioned | 2021-04-30T07:02:40Z | |
dc.date.available | 2021-04-30T07:02:40Z | |
dc.date.issued | 2020-02-01 | |
dc.identifier.citation | International Journal of Epidemiolog 49.1 (2020): 173-192 | en_US |
dc.identifier.issn | 0300-5771 (print) | es_ES |
dc.identifier.issn | 1464-368 (online) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/695061 | |
dc.description | Artículo con numerosos autores. Sólo quedan reflejados el primero, los pertenecientes a la UAM y el colectivo | es_ES |
dc.description.abstract | Background: Although high-density lipoprotein (HDL) and non-HDL cholesterol have opposite associations with coronary heart disease, multi-country reports of lipid trends only use total cholesterol (TC). Our aim was to compare trends in total, HDL and non-HDL cholesterol and the total-to-HDL cholesterol ratio in Asian and Western countries. Methods: We pooled 458 population-based studies with 82.1 million participants in 23 Asian and Western countries. We estimated changes in mean total, HDL and non-HDL cholesterol and mean total-to-HDL cholesterol ratio by country, sex and age group. Results: Since ∼1980, mean TC increased in Asian countries. In Japan and South Korea, the TC rise was due to rising HDL cholesterol, which increased by up to 0.17 mmol/L per decade in Japanese women; in China, it was due to rising non-HDL cholesterol. TC declined in Western countries, except in Polish men. The decline was largest in Finland and Norway, at ∼0.4 mmol/L per decade. The decline in TC in most Western countries was the net effect of an increase in HDL cholesterol and a decline in non-HDL cholesterol, with the HDL cholesterol increase largest in New Zealand and Switzerland. Mean total-to-HDL cholesterol ratio declined in Japan, South Korea and most Western countries, by as much as ∼0.7 per decade in Swiss men (equivalent to ∼26% decline in coronary heart disease risk per decade). The ratio increased in China. Conclusions: HDL cholesterol has risen and the total-to-HDL cholesterol ratio has declined in many Western countries, Japan and South Korea, with only a weak correlation with changes in TC or non-HDL cholesterol. | en_US |
dc.description.sponsorship | This work was supported by the Wellcome Trust (grant numbers
101506/Z/13/Z and Research Training Fellowship 203616/Z/16/Z).
R.C. acknowledges funding from the Ministry of Health of the
Czech Republic (grant number 15-27109A) | en_US |
dc.format.extent | 20 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en_US |
dc.publisher | Oxford University Press on behalf of the International Epidemiological Association | en_US |
dc.relation.ispartof | International Journal of Epidemiology | en_US |
dc.rights | © 2019 The Authors | en_US |
dc.subject.other | Blood lipids | en_US |
dc.subject.other | HDL cholesterol | en_US |
dc.subject.other | LDL cholesterol | en_US |
dc.subject.other | Multi-country study | en_US |
dc.subject.other | Total cholesterol | en_US |
dc.title | National trends in total cholesterol obscure heterogeneous changes in HDL and non-HDL cholesterol and total-to-HDL cholesterol ratio: A pooled analysis of 458 population-based studies in Asian and Western countries | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | http://doi.org/10.1093/ije/dyz099. | es_ES |
dc.identifier.doi | 10.1093/ije/dyz099 | es_ES |
dc.identifier.publicationfirstpage | 173 | es_ES |
dc.identifier.publicationissue | 1 | es_ES |
dc.identifier.publicationlastpage | 192 | es_ES |
dc.identifier.publicationvolume | 49 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Rodríguez Artalejo, Fernando (259343) | |
dc.authorUAM | Banegas Banegas, José Ramón (261477) | |
dc.facultadUAM | Facultad de Medicina | |