Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
NRF2 and primary cilia: An emerging partnership
Entity
UAM. Departamento de Bioquímica; Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM); Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
MDPI, Basel, SMwitzerlandDate
2020-06-02Citation
10.3390/antiox9060475
Antioxidants 9.6 (2020): 475
ISSN
2076-3921DOI
10.3390/antiox9060475Funded by
This work was funded by European Regional Development Fund (ERDF/FEDER)-cofunded grants from the Spanish Ministry of Economy and Competitiveness (MINECO) to F.R.G.G. (SAF2015-66568-R and RYC2013-14887). A.M.H. was supported by a FEDER-cofunded predoctoral contract from the Community of Madrid governmentProject
Gobierno de España. SAF2015-66568-R; Gobierno de España. RYC2013-14887Editor's Version
http://doi.org/10.3390/antiox9060475Subjects
Autophagy; Cancer; Ciliogenesis; Ciliopathy; Hedgehog signaling; mTOR; Non-small cell lung cancer (NSCLC); NRF2; Primary cilia; MedicinaRights
© 2020 The AuthorsAbstract
When not dividing, many cell types target their centrosome to the plasma membrane, where it nucleates assembly of a primary cilium, an antenna-like signaling structure consisting of nine concentric microtubule pairs surrounded by membrane. Primary cilia play important pathophysiological roles in many tissues, their dysfunction being associated with cancer and ciliopathies, a diverse group of congenital human diseases. Several recent studies have unveiled functional connections between primary cilia and NRF2 (nuclear factor erythroid 2-related factor 2), the master transcription factor orchestrating cytoprotective responses to oxidative and other cellular stresses. These NRF2-cilia relationships are reciprocal: primary cilia, by promoting autophagy, downregulate NRF2 activity. In turn, NRF2 transcriptionally regulates genes involved in ciliogenesis and Hedgehog (Hh) signaling, a cilia-dependent pathway with major roles in embryogenesis, stem cell function and tumorigenesis. Nevertheless, while we found that NRF2 stimulates ciliogenesis and Hh signaling, a more recent study reported that NRF2 negatively affects these processes. Herein, we review the available evidence linking NRF2 to primary cilia, suggest possible explanations to reconcile seemingly contradictory data, and discuss what the emerging interplay between primary cilia and NRF2 may mean for human health and disease.
Files in this item
Google Scholar:Martin-Hurtado, Ana
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Lastres Becker, Isabel
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Cuadrado Pastor, Antonio
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Garcia-Gonzalo, Francesc R.
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