Both HCV infection and elevated liver stiffness significantly impacts on several parameters of T-cells homeostasis in HIV-infected patients
EntityUAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (ISS-FJD)
PublisherMDPI, Basel, Switzerland
10.3390/jcm9092978Journal of Clinical Medicine 9.9 (2020): 2978
Funded byThis work was partially supported by projects PI14/00518 and RD16/0025/0013 integrated in the Spanish plan for scientific and technical research and innovation from the General Sub-Directorate for research assessment and promotion, Spanish Carlos III Institute of Health (ISCIII) co-funded by the European Regional Development Fund (ERDF). Norma Rallón is a Miguel Servet investigator from the ISCIII (CPII19/00025). María A Navarrete-Muñoz is funded by project IND2018/BMD-9651. Clara Restrepo is funded by project RD16/0025/0013. Marcial García is co-funded by RD16/0025/0013 project and an intramural research scholarship from IIS-FJD.
ProjectGobierno de España. PI14/00518; Gobierno de España. RD16/0025/0013
SubjectsHIV/HCV coinfection; T-cell homeostasis disturbances; liver stiffness; immune restoration; DAAs-based therapy; Medicina
Rights© 2020 The Authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Background: The role of hepatitis C virus (HCV) co-infection on the T-cell homeostasis disturbances in human immunodeficiency virus (HIV)-infected patients as well as its reversion after HCV eradication with direct acting antivirals (DAAs) therapy has not been yet clarified. We extensively analyzed the effect of HCV co-infection on immune parameters of HIV pathogenesis and its evolution after HCV eradication with DAAs. (2) Methods: Seventy individuals were included in the study—25 HIV-monoinfected patients, 25 HIV/HCV-coinfected patients and 20 HIV and HCV seronegative subjects. All patients were on antiretroviral therapy and undetectable HIV-viremia. Immune parameters, such as maturation, activation, apoptosis, senescence and exhaustion of T-cells were assessed by flow cytometry. Cross-sectional and longitudinal (comparing pre- and post-DAAs data in HIV/HCV coinfected patients) analyses were performed. Univariate and multivariate (general linear model and canonical discriminant analysis -CDA-) analyses were used to assess differences between groups. (3) Results—The CDA was able to clearly separate HIV/HCV coinfected from HIV-monoinfected patients, showing a more disturbed T-cells homeostasis in HIV/HCV patients, especially activation and exhaustion of T-cells. Interestingly, those perturbations were more marked in HIV/HCV patients with increased liver sti ness. Eradication of HCV with DAAs restored some but not all the T-cells homeostasis disturbances, with activation and exhaustion of e ector CD8 T-cells remaining significantly increased three months after HCV eradication. (4) Conclusions—HCV co-infection significantly impacts on several immune markers of HIV pathogenesis, especially in patients with increased liver stiffness. Eradication of HCV with DAAs ameliorates but does not completely normalize these alterations. It is of utmost relevance to explore other mechanisms underlying the immune damage observed in HIV/HCV coinfected patients with control of both HIV and HCV replication.
Google Scholar:Restrepo, Clara - Álvarez, Beatriz - Valencia, José L. - García, Marcial - Navarrete-Muñoz, María A. - Ligos, José M. - Cabello, Alfonso - Prieto, Laura - Nistal, Sara - Montoya, María - Górgolas, Miguel - Rallón, Norma - Benito, José M.
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