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Hepatic encephalopathy-associated cerebral vasculopathy in acute-on-chronic liver failure: Alterations on endothelial factor release and influence on cerebrovascular function
dc.contributor.author | Caracuel, Laura | |
dc.contributor.author | Sastre, Esther | |
dc.contributor.author | Callejo, María | |
dc.contributor.author | Rodrigues Díez, Raquel | |
dc.contributor.author | García Redondo, Ana Belén | |
dc.contributor.author | Prieto Nieto, María Isabel | |
dc.contributor.author | Nieto, Carlos | |
dc.contributor.author | Salaices Sánchez, Mercedes | |
dc.contributor.author | Aller, Ma Ángeles | |
dc.contributor.author | Arias, Jaime | |
dc.contributor.author | Blanco Rivero, Javier | |
dc.contributor.other | UAM. Departamento de Cirugía | es_ES |
dc.contributor.other | UAM. Departamento de Farmacología | es_ES |
dc.contributor.other | UAM. Departamento de Fisiología | es_ES |
dc.contributor.other | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) | |
dc.date.accessioned | 2021-06-03T09:23:54Z | |
dc.date.available | 2021-06-03T09:23:54Z | |
dc.date.issued | 2020-11-20 | |
dc.identifier.citation | Frontiers in Physiology 11.Nov (2020): 593371 | en_US |
dc.identifier.issn | 1664-042X | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/695645 | |
dc.description.abstract | The acute-on-chronic liver failure (ACLF) is a syndrome characterized by liver decompensation, hepatic encephalopathy (HE) and high mortality. We aimed to determine the mechanisms implicated in the development of HE-associated cerebral vasculopathy in a microsurgical liver cholestasis (MHC) model of ACLF. Microsurgical liver cholestasis was induced by ligating and extracting the common bile duct and four bile ducts. Sham-operated and MHC rats were maintained for eight postoperative weeks Bradykinin-induced vasodilation was greater in middle cerebral arteries from MHC rats. Both Nω-Nitro-L-arginine methyl ester and indomethacin diminished bradykinin-induced vasodilation largely in arteries from MHC rats. Nitrite and prostaglandin (PG) F releases were increased, whereas thromboxane (TX) B was not modified in arteries from MHC. Expressions of endothelial nitric oxide synthase (eNOS), inducible NOS, and cyclooxygenase (COX) 2 were augmented, and neuronal NOS (nNOS), COX-1, PGI synthase, and TXA S were unmodified. Phosphorylation was augmented for eNOS and unmodified for nNOS. Altogether, these endothelial alterations might collaborate to increase brain blood flow in HE. 1α 2 2 2 | en_US |
dc.description.sponsorship | This research was funded by the Ministerio de Economía y Competitividad (SAF2016-80305-P), CiberCV (Grant number: CB16/11/00286), the European Regional Development Grant (FEDER) (Comunidad de Madrid, grant number B2017/BMD- 3676), and R C D projects for young researchers, Universidad Autónoma de Madrid-Comunidad de Madrid (SI1-PJI-2019- 00321). RR-D received a fellowship from Juan de la Cierva Program (IJCI-2017-31399). | en_US |
dc.format.extent | 13 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en_US |
dc.publisher | Frontiers Media | en_US |
dc.relation.ispartof | Frontiers in Physiology | en_US |
dc.rights | © 2020 Caracuel, Sastre, Callejo, Rodrigues-Díez, García-Redondo, Prieto, Nieto, Salaices, Aller, Arias and Blanco-Rivero. | es_ES |
dc.subject.other | acute-on-chronic liver failure | en_US |
dc.subject.other | bradykinin | en_US |
dc.subject.other | cerebral vasculature | en_US |
dc.subject.other | hepatic encephalopathy | en_US |
dc.subject.other | nitric oxide | en_US |
dc.subject.other | prostaglandin I 2 | en_US |
dc.title | Hepatic encephalopathy-associated cerebral vasculopathy in acute-on-chronic liver failure: Alterations on endothelial factor release and influence on cerebrovascular function | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | http://doi.org/10.3389/fphys.2020.593371 | es_ES |
dc.identifier.doi | 10.3389/fphys.2020.593371 | es_ES |
dc.identifier.publicationfirstpage | 593371-1 | es_ES |
dc.identifier.publicationissue | Nov. | es_ES |
dc.identifier.publicationlastpage | 593371-13 | es_ES |
dc.identifier.publicationvolume | 11 | es_ES |
dc.relation.projectID | Gobierno de España. SAF2016-80305-P | es_ES |
dc.relation.projectID | Gobierno de España. CB16/11/00286 | es_ES |
dc.relation.projectID | Comunidad de Madrid. B2017/BMD-3676/AORTASANA | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | García Redondo, Ana Belén (263977) | |
dc.authorUAM | Prieto Nieto, María Isabel (261977) | |
dc.authorUAM | Salaices Sánchez, Mercedes (260920) | |
dc.authorUAM | Blanco Rivero, Javier (260695) | |
dc.authorUAM | Rodrigues Díez, Raquel (324127) | |
dc.facultadUAM | Facultad de Medicina | |
dc.institutoUAM | Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ) |