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dc.contributor.authorMartos Moreno, Gabriel Ángel 
dc.contributor.authorMartínez-Villanueva, Julián
dc.contributor.authorGonzález-Leal, Rocío
dc.contributor.authorBarrios, Vicente
dc.contributor.authorSirvent, Sara
dc.contributor.authorHawkins, Federico
dc.contributor.authorChowen, Julie A.
dc.contributor.authorArgente Oliver, Jesús 
dc.contributor.otherUAM. Departamento de Pediatríaes_ES
dc.date.accessioned2021-06-01T09:16:50Z
dc.date.available2021-06-01T09:16:50Z
dc.date.issued2020-10-09
dc.identifier.citationFrontiers in Pediatrics 8.October (2020): 551103en_US
dc.identifier.issn2296-2360es_ES
dc.identifier.urihttp://hdl.handle.net/10486/695661
dc.description.abstractBackground: Body fat content and distribution in childhood is influenced by sex and puberty, but interethnic differences in the percentage and distribution of body fat also exist. The abdominal visceral/subcutaneous fat ratio has been the main feature of body fat distribution found to associate with the serum adipokine profile and metabolic derangement in adulthood obesity. This has also been assumed for childhood obesity despite the known singularities of this disease in the pediatric age in comparison to adults. Objective: We aimed to investigate the effect of ethnicity, together with sex and pubertal status, on body fat content and distribution, serum adipokine profile, metabolic impairment and liver steatosis in children and adolescents with obesity. Patients and Methods: One hundred and fifty children with obesity (50% Caucasians/50% Latinos; 50% males/50% females) were studied. Body fat content and distribution were studied by whole body DXA-scan and abdominal magnetic resonance, and their relationships with liver steatosis (as determined by ultrasonography), glycemia, insulinemia, lipid metabolism, uric acid, total and HMW-adiponectin, leptin, leptin-receptor, and sex steroid levels were explored. Results: Latino patients had more severe truncal obesity (higher trunk/lower limb fat ratio, odds ratio 10.00; p < 0.05) and higher prevalence of liver steatosis than Caucasians regardless of sex or pubertal status, but there were no difference in the visceral/subcutaneous abdominal fat ratio, except for pubertal females. A higher trunk/lower limb fat ratio, but not the visceral/subcutaneous abdominal fat ratio, was associated with adipokine profile impairment (higher free leptin index and lower adiponectin levels), insulin resistance and dyslipidemia, and was further enhanced when liver steatosis was present (p < 0.05). A higher abdominal visceral/subcutaneous fat ratio was observed in prepubertal children (p < 0.01), except for Latino females, whereas predominant subcutaneous fat deposition was observed in adolescents. Conclusion: Ethnicity is one of the main determinants of increased trunk body fat accumulation in Latino children with obesity, which is best estimated by the trunk/lower limb fat ratio and related to the development of metabolic derangement and liver steatosis.en_US
dc.description.sponsorshipThis work was supported by CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN) and the Instituto de Salud Carlos III, FIS (FIS grant numbers PI09/91060; FIS 10/00747; FIS 13/01295; and FIS 16/00485)en_US
dc.format.extent11 pag.es_ES
dc.format.mimetypeapplication/pdfen_US
dc.language.isoengen_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofFrontiers in Pediatricsen_US
dc.rights© 2020 Martos-Moreno, Martínez-Villanueva, González-Leal, Barrios, Sirvent, Hawkins, Chowen and Argentees_ES
dc.subject.otherabdominal magnetic resonanceen_US
dc.subject.otheradipokinesen_US
dc.subject.otherbody fat distributionen_US
dc.subject.otherchildhood obesityen_US
dc.subject.otherDXA-scanen_US
dc.subject.otherethnicityen_US
dc.subject.otherinsulin resistanceen_US
dc.subject.othersteatosisen_US
dc.titleEthnicity strongly influences body fat distribution determining serum adipokine profile and metabolic derangement in childhood obesityen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttp://doi.org/10.3389/fped.2020.551103es_ES
dc.identifier.doi10.3389/fped.2020.551103es_ES
dc.identifier.publicationfirstpage551103-1es_ES
dc.identifier.publicationissueOctoberen_US
dc.identifier.publicationlastpage551103-11es_ES
dc.identifier.publicationvolume8es_ES
dc.relation.projectIDGobierno de España. PI09/91060es_ES
dc.relation.projectIDGobierno de España. FIS 10/00747es_ES
dc.relation.projectIDGobierno de España. FIS 13/01295es_ES
dc.relation.projectIDGobierno de España. FIS 16/00485es_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMMartos Moreno, Gabriel Ángel (101491)
dc.authorUAMArgente Oliver, Jesús (100008)
dc.facultadUAMFacultad de Medicina


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