Inflammatory-related clinical and metabolic outcomes in Covid-19 patients
EntityUAM. Departamento de Medicina
10.1155/2020/2914275Mediators of Inflammation 2020 (2020): 2914275
Funded byCIBERon Instituto Carlos III in Madrid is credited for institutional support.
SubjectsSARS-CoV-2; Inflamatory; Pneumonia; Intensive Care Unit (ICU); Medicina
Rights© 2020 Maria Martinez-Urbistondo et al.
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Background. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-COV-2) infection elicits inflammatory manifestations that relate with a “cytokine storm.” Objective. The aim of this research was to assess the role of circulating interleukin 6 (IL-6) levels and other inflammatory markers in patients with coronavirus disease 2019 (COVID-19) on metabolic functions and accompanying clinical complications. Patients and Methods. A total of 165 patients diagnosed with COVID-19 pneumonia were examined for medical features and inflammatory markers such as blood IL-6, CRP, ferritin, LDH, neutrophil/lymphocyte index (NLI), D-Dimer, and Red Cell Distribution Width (RDW). Regression analyses concerning electronically collected medical data were adjusted by appropriate factors and confounding variables. Results. Plasma IL-6 determinations evidenced a consistent association with hospital stay days, Intensive Care Unit (ICU) admission, and mortality rates. Similar trends were found for other proinflammatory variables, where ferritin and NLI showed a remarkable value as surrogates. Hyperglycaemia and the Charlson Comorbidity Index Score were positively associated with the inflammatory response induced by the SARS-COV-2 infection. An unhealthy lifestyle such as smoking and alcoholic drinks consumption as well as excessive body adiposity influenced inflammatory-related outcomes in the screened patients. Conclusion. IL-6 together with other inflammatory biomarkers accompanied poor clinical and metabolic outcomes in COVID-19-infected patients. IL-6 may result in a suitable proxy to individually categorise patients in order to manage this infectious pandemic.
Google Scholar:Martinez-Urbistondo, Maria - Mora-Vargas, Alberto - Expósito-Palomo, Esther - Castejón, Raquel - Citores, M. Jesús - Rosado, Silvia - de Mendoza, Carmen - Baños, Isolina - Fernández-Cruz, Ana - Daimiel, Lidia - San-Cristóbal, Rodrigo - Vargas, Juan Antonio - Martinez, J. Alfredo
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