Simultaneous supercritical fluid extraction of heather (Calluna vulgaris L.) and marigold (Calendula officinalis L.) and anti-inflammatory activity of the extracts
Entity
UAM. Departamento de Química Física AplicadaPublisher
MDPIDate
2019-05-31Citation
10.3390/app9112245
Applied Sciences 9.11 (2019): 2245
ISSN
2076-3417 (online)DOI
10.3390/app9112245Funded by
The authors gratefully acknowledge the financial support from Ministerio de Economía y Competitividad of Spain (project AGL2013-48943-C2) and the Comunidad Autónoma de Madrid (ALIBIRD, project number S2013/ABI-2728)Project
Gobierno de España. AGL2013-48943-C2; Comunidad de Madrid. S2013/ABI-2728/ALIBIRDEditor's Version
https://doi.org/10.3390/app9112245Subjects
Anti-inflammatory; Combined extraction; Heather; Marigold; Supercritical fluid extraction; Triterpenic acids; QuímicaRights
© 2019 by the authorsAbstract
Heather (Calluna vulgaris L.) and marigold (Calendula officinalis L.) are two rich sources of bioactive pentacyclic triterpenes. The supercritical carbon dioxide (SCCO2) extraction of these two plants was explored at a pressure range of 25–50 MPa, 50 ºC, with or without fractionation, different extraction times (1.5–4.0 h) and using ethanol as a co-solvent (0 and 10% w/w). In order to determine potential synergisms, a combined extraction (heather + marigold 50:50) was also studied. In general, higher extraction yields were achieved when the co-solvent was added. Higher concentrations of total triterpenic acids were obtained in heather extracts, specially using ethanol. The co-solvent did not increase the terpene concentration in marigold extracts. For the combined extraction, an antagonist effect in the triterpene concentration was observed in absence of a co-solvent, whereas a synergistic effect was exhibited in its presence, especially for ursolic acid. In general, the extracts showed a certain anti-inflammatory effect, although a straight correlation with the analyzed triterpenic acids concentration was not exhibited. Moreover, the combined extraction exposed a similar anti-inflammatory activity in comparison with the individual plant extracts
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Google Scholar:Villanueva-Bermejo, David
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Vázquez, Erika
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Villalva, Marisol
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Santoyo Díez, Susana
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Fornari Reale, Tiziana
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Reglero Rada, Guillermo J.
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Rodríguez García-Risco, Mónica
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