Monocyte chemoattractant protein-1 Is an independent predictor of coronary artery ectasia in patients with acute coronary syndrome
Author
Franco-Peláez, Juan Antonio; Martín-Reyes, Roberto; Pello-Lázaro, Ana María; Aceña Navarro, Álvaro



Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Publisher
MDPI, Basel, SwitzerlandDate
2020-09-21Citation
10.3390/jcm9093037
Journal of Clinical Medicine 9.9 (2020): 3037
ISSN
2077-0383DOI
10.3390/jcm9093037Funded by
This work was supported by grants from the following: Fondo de Investigaciones Sanitarias (PI05/0451, PI05/1497, PI05/52475, PI05/1043, PS09/01405, and PI10/00072, PI14/01567, PI17/01615): http://www.isciii.es/ISCIII/ es/contenidos/fd-investigacion/fd-financiacion/convocatorias-ayudas-accion-estrategica-salud.shtml; Spanish Society of Cardiology; Spanish Heart Foundation. http://www.secardiologia.es/; Spanish Society of Arteriosclerosis.www.searteriosclerosis.org; CiberCV. http://www.cibercv.es/; RECAVA (RD06/0014/0035); www.recava.com; Fundación Lilly. https://www.lilly.es/nuestra-compania/fundacion-lilly-folder; Instituto de Salud Carlos III FEDER (FJD biobank: RD09/0076/00101); http://www.isciii.es/; and AbbVie Laboratories. http://www.abbvie.es/.Project
Gobierno de España. PI05/0451; Gobierno de España. PI05/1497; Gobierno de España. PI05/52475; Gobierno de España. PI05/1043; Gobierno de España. PS09/01405; Gobierno de España. PI10/00072; Gobierno de España. PI14/01567; Gobierno de España. PI17/01615; Gobierno de España. RD06/0014/0035; Gobierno de España. RD09/0076/00101Editor's Version
http://dx.doi.org/10.3390/jcm9093037Subjects
coronary artery ectasia; monocyte chemoattractant protein-1; low-density lipoprotein; acute atherotrombotic events; coronary artery disease; MedicinaRights
© 2020 The AuthorsAbstract
Our purpose was to assess a possible association of inflammatory, lipid and mineral
metabolism biomarkers with coronary artery ectasia (CAE) and to determine a possible association
of this with acute atherotrombotic events (AAT).We studied 270 patients who underwent coronary
angiography during an acute coronary syndrome 6 months before. Plasma levels of several
biomarkers were assessed, and patients were followed during a median of 5.35 (3.88–6.65) years.
Two interventional cardiologists reviewed the coronary angiograms, diagnosing CAE according to
previously published criteria in 23 patients (8.5%). Multivariate binary logistic regression analysis
was used to search for independent predictors of CAE. Multivariate analysis revealed that, aside
from gender and a diagnosis of dyslipidemia, only monocyte chemoattractant protein-1 (MCP-1)
(OR = 2.25, 95%CI = (1.35–3.76) for each increase of 100 pg/mL, p = 0.001) was independent predictor
of CAE, whereas mineral metabolism markers or proprotein convertase subtilisin/kexin type 9
were not. Moreover, CAE was a strong predictor of AAT during follow-up after adjustment for other
clinically relevant variables (HR = 2.67, 95%CI = (1.22–5.82), p = 0.013). This is the first report showing
that MCP-1 is an independent predictor of CAE, suggesting that CAE and coronary artery disease
may share pathogenic mechanisms. Furthermore, CAE was associated with an increased incidence of AAT
Files in this item
Google Scholar:Franco-Peláez, Juan Antonio
-
Martín-Reyes, Roberto
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Pello-Lázaro, Ana María
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Aceña Navarro, Álvaro
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Lorenzo González, Óscar
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Martín Ventura, José Luis
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Blanco-Colio, Luis
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González-Casaus, María Luisa
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Hernández-González, Ignacio
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Carda, Rocío
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Martín-Mariscal, María Luisa
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Egido, Jesús
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Tuñón Fernández, José Luis
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