Differential deleterious impact of highly saturated versus monounsaturated fat intake on vascular function, structure, and mechanics in mice
Entidad
UAM. Departamento de PediatríaEditor
MDPI, Basel, SwitzerlandFecha de edición
2021-03-19Cita
10.3390/nu13031003
Nutrients 13.3 (2021): 1003.
ISSN
2072-6643DOI
10.3390/nu13031003Financiado por
This research was funded by Ministerio de Economía y Competitividad (BFU2017-82565- C2-2-R, BFU2017-82565-C2-1-R and BFU2016-78556-R), FUSP-CEU and Grupos Universidad Complutense de Madrid (GR-921641).Proyecto
Gobierno de España. BFU2017-82565- C2-2-R; Gobierno de España. BFU2017-82565-C2-1-R; Gobierno de España. BFU2016-78556-RVersión del editor
https://doi.org/10.3390/nu13031003Materias
Arterial stiffness; Collagen; Endothelial dysfunction; Monounsaturated fatty acids; Nitric oxide; Purified high‐fat diets; Saturated fatty acids; Vascular remodeling; MedicinaDerechos
© 2021 The authorsResumen
Vegetable oils such as palm oil (enriched in saturated fatty acids, SFA) and high‐oleic‐acid sunflower oil (HOSO, containing mainly monounsaturated fatty acids, MUFA) have emerged as the most common replacements for trans‐fats in the food industry. The aim of this study is to analyze the impact of SFA and MUFA‐enriched high‐fat (HF) diets on endothelial function, vascular remodeling, and arterial stiffness compared to commercial HF diets. Five‐week‐old male C57BL6J mice were fed a standard (SD), a HF diet enriched with SFA (saturated oil‐enriched Food, SOLF), a HF diet enriched with MUFA (unsaturated oil‐enriched Food, UOLF), or a commercial HF diet for 8 weeks. Vascular function was analyzed in the thoracic aorta. Structural and mechanical parameters were assessed in mesenteric arteries by pressure myography. SOLF, UOLF, and HF diet reduced contractile responses to phenylephrine and induced endothelial dysfunction in the thoracic aorta. A significant increase in the β‐index, and thus in arterial stiffness, was also detected in mesenteric arteries from the three HF groups, due to enhanced deposition of collagen in the vascular wall. SOLF also induced hypotrophic inward remodeling. In conclusion, these data demonstrate a deleterious effect of HF feeding on obesity‐related vascular alterations that is exacerbated by SFA.
Lista de ficheros
Google Scholar:Vega‐martín, Elena
-
Gil‐ortega, Marta
-
González‐blázquez, Raquel
-
Benedito, Sara
-
Fernández‐felipe, Jesús
-
Ruiz‐gayo, Mariano
-
Del Olmo, Nuria
-
Chowen, Julie A.
-
Frago Fernández, Laura María
-
Somoza, Beatriz
-
Fernández‐alfonso, María S.
Lista de colecciones del ítem
Registros relacionados
Mostrando ítems relacionados por título, autor, creador y materia.