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dc.contributor.authorVega‐martín, Elena
dc.contributor.authorGil‐ortega, Marta
dc.contributor.authorGonzález‐blázquez, Raquel
dc.contributor.authorBenedito, Sara
dc.contributor.authorFernández‐felipe, Jesús
dc.contributor.authorRuiz‐gayo, Mariano
dc.contributor.authorDel Olmo, Nuria
dc.contributor.authorChowen, Julie A.
dc.contributor.authorFrago Fernández, Laura María 
dc.contributor.authorSomoza, Beatriz
dc.contributor.authorFernández‐alfonso, María S.
dc.contributor.otherUAM. Departamento de Pediatríaes_ES
dc.date.accessioned2021-09-13T17:13:57Z
dc.date.available2021-09-13T17:13:57Z
dc.date.issued2021-03-19
dc.identifier.citationNutrients 13.3 (2021): 1003.en_US
dc.identifier.issn2072-6643es_ES
dc.identifier.urihttp://hdl.handle.net/10486/697545
dc.description.abstractVegetable oils such as palm oil (enriched in saturated fatty acids, SFA) and high‐oleic‐acid sunflower oil (HOSO, containing mainly monounsaturated fatty acids, MUFA) have emerged as the most common replacements for trans‐fats in the food industry. The aim of this study is to analyze the impact of SFA and MUFA‐enriched high‐fat (HF) diets on endothelial function, vascular remodeling, and arterial stiffness compared to commercial HF diets. Five‐week‐old male C57BL6J mice were fed a standard (SD), a HF diet enriched with SFA (saturated oil‐enriched Food, SOLF), a HF diet enriched with MUFA (unsaturated oil‐enriched Food, UOLF), or a commercial HF diet for 8 weeks. Vascular function was analyzed in the thoracic aorta. Structural and mechanical parameters were assessed in mesenteric arteries by pressure myography. SOLF, UOLF, and HF diet reduced contractile responses to phenylephrine and induced endothelial dysfunction in the thoracic aorta. A significant increase in the β‐index, and thus in arterial stiffness, was also detected in mesenteric arteries from the three HF groups, due to enhanced deposition of collagen in the vascular wall. SOLF also induced hypotrophic inward remodeling. In conclusion, these data demonstrate a deleterious effect of HF feeding on obesity‐related vascular alterations that is exacerbated by SFA.en_US
dc.description.sponsorshipThis research was funded by Ministerio de Economía y Competitividad (BFU2017-82565- C2-2-R, BFU2017-82565-C2-1-R and BFU2016-78556-R), FUSP-CEU and Grupos Universidad Complutense de Madrid (GR-921641).en_US
dc.format.extent13 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen_US
dc.publisherMDPI, Basel, Switzerlanden_US
dc.relation.ispartofNutrientsen_US
dc.rights© 2021 The authorsen_US
dc.subject.otherArterial stiffnessen_US
dc.subject.otherCollagenen_US
dc.subject.otherEndothelial dysfunctionen_US
dc.subject.otherMonounsaturated fatty acidsen_US
dc.subject.otherNitric oxideen_US
dc.subject.otherPurified high‐fat dietsen_US
dc.subject.otherSaturated fatty acidsen_US
dc.subject.otherVascular remodelingen_US
dc.titleDifferential deleterious impact of highly saturated versus monounsaturated fat intake on vascular function, structure, and mechanics in miceen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/nu13031003es_ES
dc.identifier.doi10.3390/nu13031003es_ES
dc.identifier.publicationfirstpage1003.-1es_ES
dc.identifier.publicationissue3es_ES
dc.identifier.publicationlastpage1003-13es_ES
dc.identifier.publicationvolume13es_ES
dc.relation.projectIDGobierno de España. BFU2017-82565- C2-2-Res_ES
dc.relation.projectIDGobierno de España. BFU2017-82565-C2-1-Res_ES
dc.relation.projectIDGobierno de España. BFU2016-78556-Res_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMFrago Fernández, Laura María (101490)
dc.facultadUAMFacultad de Medicina


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