dc.contributor.author | Mougey, Edward B. | |
dc.contributor.author | Nguyen, Vivian | |
dc.contributor.author | Gutiérrez Junquera, Carolina | |
dc.contributor.author | Fernández-Fernández, Sonia | |
dc.contributor.author | Cilleruelo, Maria Luz | |
dc.contributor.author | Rayo, Ana | |
dc.contributor.author | Borrell, Belén | |
dc.contributor.author | Román Riechmann, Enriqueta | |
dc.contributor.author | González-Lois, Carmen | |
dc.contributor.author | Chao, Montserrat | |
dc.contributor.author | Al-Atrash, Hadeel | |
dc.contributor.author | Franciosi, James P. | |
dc.contributor.other | UAM. Departamento de Anatomía Patológica | es_ES |
dc.contributor.other | UAM. Departamento de Pediatría | es_ES |
dc.date.accessioned | 2021-09-29T11:28:16Z | |
dc.date.available | 2021-09-29T11:28:16Z | |
dc.date.issued | 2021-10-01 | |
dc.identifier.citation | Clinical Gastroenterology and Hepatology 19.10 (2020): 2046-2053 | en_US |
dc.identifier.issn | 1542-3565 | es_ES |
dc.identifier.uri | http://hdl.handle.net/10486/697960 | |
dc.description.abstract | Background & Aims: Based on histologic features, variants in STAT6 are associated with a poor initial response to proton pump inhibitor (PPI) therapy in pediatric patients with eosinophilic esophagitis (EoE). We investigated whether these genetic variants are associated with a poor long-term response in children with EoE who initially responded to PPI therapy. Methods: We performed a prospective longitudinal cohort study of children ages 2 to 16 years who met the diagnostic criteria for EoE (≥15 eosinophils/high-power field [eos/hpf]), responded to 8 weeks of treatment with 2 mg/kg/d PPI (<15 eos/hpf), and whose dose then was reduced to 1 mg/kg/d PPI (maintenance therapy) for 1 year, at which point biopsy specimens were collected by endoscopy. Genomic DNA was isolated from formalin-fixed paraffin-embedded biopsy tissue and was genotyped for variants of STAT6. Remission of inflammation was assessed at eos/hpf thresholds of <15 and ≤5. Results: Among 73 patients who received 1 mg/kg/d PPI maintenance therapy for 1 year, 13 patients (18%) had 6 to 14 eos/hpf, 36 patients (49%) had 5 or fewer eos/hpf, and 24 patients (33%) relapsed to EoE (≥15 eos/hpf). Carriage of any of 3 STAT6 variants in linkage disequilibrium (r2 ≥0.8; rs324011, rs167769, or rs12368672) was associated with a 2.3- to 2.8-fold increase in the odds of EoE relapse, and with a 2.8- to 4.1-fold increase in the odds of having 6 to 14 eos/hpf. For rs324011, the odds ratio [95% CI] for relapse was 2.77 [1.11, 6.92]; P = .029, and the odds ratio [95% CI] for having 6 to 14 eos/hpf was 3.06 [1.27, 7.36]; P = .012. Conclusions: Pediatric EoE patients who initially respond to PPI therapy and carry STAT6 variants rs324011, rs167769, or rs12368672 are at increased risk of relapse after 1 year of PPI maintenance therapy. | en_US |
dc.format.extent | 10 pag. | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier, Inc. | en_US |
dc.relation.ispartof | Clinical Gastroenterology and Hepatology | en_US |
dc.rights | © 2020 by the AGA Institute. | en_US |
dc.subject.other | Biomarker | en_US |
dc.subject.other | Esophagus | en_US |
dc.subject.other | Immune Response | en_US |
dc.subject.other | Response to Treatment | en_US |
dc.title | STAT6 variants associate with relapse of fosinophilic esophagitis in patients receiving long-term proton pump inhibitor therapy | en_US |
dc.type | article | en |
dc.subject.eciencia | Medicina | es_ES |
dc.relation.publisherversion | https://doi.org/10.1016/j.cgh.2020.08.020 | es_ES |
dc.identifier.doi | 10.1016/j.cgh.2020.08.020 | es_ES |
dc.identifier.publicationfirstpage | 2046 | es_ES |
dc.identifier.publicationissue | 10 | es_ES |
dc.identifier.publicationlastpage | 2053 | es_ES |
dc.identifier.publicationvolume | 19 | es_ES |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.rights.cc | Reconocimiento – NoComercial – SinObraDerivada | es_ES |
dc.rights.accessRights | openAccess | en |
dc.authorUAM | Gutiérrez Junquera, Carolina (262096) | |
dc.authorUAM | Cilleruelo Pascual, María Luz (279714) | |
dc.authorUAM | Román Riechmann, Enriqueta (262097) | |
dc.authorUAM | González Lois, María Del Carmen (262342) | |
dc.facultadUAM | Facultad de Medicina | |