The key comorbidities in patients with rheumatoid arthritis: A narrative review
Entity
UAM. Departamento de MedicinaPublisher
MDPI, Basel, SwitzerlandDate
2021-02-01Citation
10.3390/jcm10030509
Journal of Clinical Medicine 10.3 (2021): 509
ISSN
2077-0383DOI
10.3390/jcm10030509Funded by
Medical writing support and the APC was funded by Fresenius Kabi SwissBioSim GmbHEditor's Version
https://doi.org/10.3390/jcm10030509Subjects
Cardiovascular disease; Comorbidities; Extra-articular manifestations; Infections; Lymphoma; Nonmelanoma skin cancers; Rheumatoid arthritis; Tumour necrosis factor; MedicinaRights
© 2021 The authorsAbstract
Comorbidities in patients with rheumatoid arthritis (RA) are often associated with poor health outcomes and increased mortality. Treatment decisions should take into account these comor-bidities due to known or suspected associations with certain drug classes. In clinical practice, it is critical to balance potential treatment benefit against the possible risks for comorbidities as well as the articular manifestations of RA. This review summarises the current literature relating to prevalence and risk factors for the important comorbidities of cardiovascular disease, infections, lymphomas and nonmelanoma skin cancers in patients with RA. The impact on patient outcomes and the interplay between these comorbidities and the therapeutic options currently available, including tumour necrosis factor inhibitors and newer biological therapies, are also explored. As newer RA therapies are developed, and patients gain wider and earlier access to advanced therapies, in part due to the emergence of biosimilars, it is important to consider the prevention or treatment of comorbidities as part of the overall management of RA.
Files in this item
Google Scholar:Taylor, Peter C.
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Atzeni, Fabiola
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Balsa Criado, Alejandro
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Gossec, Laure
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Müller-Ladner, Ulf
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Pope, Janet
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