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Gender-based differences by age range in patients hospitalized with covid-19: A spanish observational cohort study

Author
Josa-Laorden, Claudia; Crestelo-Vieitez, Anxela; Del Mar García Andreu, María; Rubio-Rivas, Manuel; Sánchez, Marcos; Toledo Samaniego, Neera; Arnalich Fernández, Franciscountranslated; Iguaran Bermudez, Rosario; Fonseca Aizpuru, Eva Ma; Núñez, Juan Antonio Vargas; Fontan, Paula Maria Pesqueira; Ballesteros, Jorge Serrano; Castro, Santiago Jesús Freire; Fernández, Melani Pestaña; García, Alba Viana; Rodriguez, Victoria Nuñez; Giner-Galvañ, Vicente; Sánchez, Francisco Javier Carrasco; Milián, Almudena Hernández; Cobos-Siles, Marta; Lecumberri, Jose Javier Napal; García, Virginia Herrero; Pérez, Maria de los Reyes Pascual; Núñez-Cortés, Jesús Millán; Rojo, José Manuel Casas
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)
Publisher
MDPI, Basel, Switzerland
Date
2021-02-25
Citation
10.3390/jcm10050899
Journal of Clinical Medicine 10.5 (2021): 899
 
 
 
ISSN
2077-0383
DOI
10.3390/jcm10050899
Editor's Version
https://doi.org/ 10.3390/jcm10050899
Subjects
Coronavirus; COVID-19; Gender differences; SARS-CoV-2; Spain; Medicina
URI
http://hdl.handle.net/10486/698080
Rights
© 2021 The authors

Abstract

There is some evidence that male gender could have a negative impact on the prognosis and severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The aim of the present study was to compare the characteristics of coronavirus disease 2019 (COVID-19) between hospitalized men and women with confirmed SARS-CoV-2 infection. This multicenter, retrospective, observational study is based on the SEMI-COVID-19 Registry. We analyzed the differences between men and women for a wide variety of demographic, clinical, and treatment variables, and the sex distribution of the reported COVID-19 deaths, as well as intensive care unit (ICU) admission by age subgroups. This work analyzed 12,063 patients (56.8% men). The women in our study were older than the men, on average (67.9 vs. 65.7 years; p < 001). Bilateral condensation was more frequent among men than women (31.8% vs. 29.9%; p = 0.007). The men needed non-invasive and invasive mechanical ventilation more frequently (5.6% vs. 3.6%, p < 0.001, and 7.9% vs. 4.8%, p < 0.001, respectively). The most prevalent complication was acute respiratory distress syndrome, with severe cases in 19.9% of men (p < 0.001). In men, intensive care unit admission was more frequent (10% vs. 6.1%; p < 0.001) and the mortality rate was higher (23.1% vs. 18.9%; p < 0.001). Regarding mortality, the differences by gender were statistically significant in the age groups from 55 years to 89 years of age. A multivariate analysis showed that female sex was significantly and independently associated with a lower risk of mortality in our study. Male sex appears to be related to worse progress in COVID-19 patients and is an independent prognostic factor for mortality. In order to fully understand its prognostic impact, other factors associated with sex must be considered.
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Google™ Scholar:Josa-Laorden, Claudia - Crestelo-Vieitez, Anxela - Del Mar García Andreu, María - Rubio-Rivas, Manuel - Sánchez, Marcos - Toledo Samaniego, Neera - Arnalich Fernández, Francisco - Iguaran Bermudez, Rosario - Fonseca Aizpuru, Eva Ma - Núñez, Juan Antonio Vargas - Fontan, Paula Maria Pesqueira - Ballesteros, Jorge Serrano - Castro, Santiago Jesús Freire - Fernández, Melani Pestaña - García, Alba Viana - Rodriguez, Victoria Nuñez - Giner-Galvañ, Vicente - Sánchez, Francisco Javier Carrasco - Milián, Almudena Hernández - Cobos-Siles, Marta - Lecumberri, Jose Javier Napal - García, Virginia Herrero - Pérez, Maria de los Reyes Pascual - Núñez-Cortés, Jesús Millán - Rojo, José Manuel Casas

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  • Producción científica en acceso abierto de la UAM [15094]

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