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dc.contributor.authorViedma, Esther
dc.contributor.authorDahdouh, Elias
dc.contributor.authorGonzález-Alba, José María
dc.contributor.authorGonzález-Bodi, Sara
dc.contributor.authorMartínez-García, Laura
dc.contributor.authorLázaro-Perona, Fernando
dc.contributor.authorRecio, Raúl
dc.contributor.authorRodríguez-Tejedor, María
dc.contributor.authorFolgueira, María Dolores
dc.contributor.authorCantón, Rafael
dc.contributor.authorDelgado, Rafael
dc.contributor.authorGarcía Rodríguez, Julio 
dc.contributor.authorGalán, Juan Carlos
dc.contributor.authorMingorance, Jesús
dc.contributor.otherUAM. Departamento de Medicina Preventiva y Salud Pública y Microbiologíaes_ES
dc.contributor.otherInstituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)es_ES
dc.date.accessioned2021-10-04T13:57:29Z
dc.date.available2021-10-04T13:57:29Z
dc.date.issued2021-02-22
dc.identifier.citationMicroorganisms 9.2 (2021): 454en_US
dc.identifier.issn2076-2607es_ES
dc.identifier.urihttp://hdl.handle.net/10486/698081
dc.description.abstractSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in Madrid, Spain, on 25 February 2020. It increased in frequency very fast and by the end of May more than 70,000 cases had been confirmed by reverse transcription-polymerase chain reaction (RT-PCR). To study the lineages and the diversity of the viral population during this first epidemic wave in Madrid we sequenced 224 SARS-CoV-2 viral genomes collected from three hospitals from February to May 2020. All the known major lineages were found in this set of samples, though B.1 and B.1.5 were the most frequent ones, accounting for more than 60% of the sequences. In parallel with the B lineages and sublineages, the D614G mutation in the Spike protein sequence was detected soon after the detection of the first coronavirus disease 19 (COVID-19) case in Madrid and in two weeks became dominant, being found in 80% of the samples and remaining at this level during all the study periods. The lineage composition of the viral population found in Madrid was more similar to the European population than to the publicly available Spanish data, underlining the role of Madrid as a national and international transport hub. In agreement with this, phylodynamic analysis suggested multiple independent entries before the national lockdown and air transportation restrictions.en_US
dc.description.sponsorshipThis research was partially supported through the European Commission Horizon 2020 Framework Programme (VIRUSCAN, FETPROACT-2016). E.D. was recipient of a Marie Skłodowska- Curie Individual Fellowship (Grant Agreement number 796084). E.V. is supported by the Subprograma Juan Rodés, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spain (JR18/00048). R.R. is supported by the Subprograma Río Hortega, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades, Spain (CM19/00229).en_US
dc.format.extent11 pag.es_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen_US
dc.publisherMDPI, Basel, Switzerlanden_US
dc.relation.ispartofMicroorganismsen_US
dc.rights© 2021 The authorsen_US
dc.subject.otherCOVID-19es_ES
dc.subject.otherGenome sequencesen_US
dc.subject.otherSARS-CoV-2en_US
dc.titleGenomic epidemiology of SARS-CoV-2 in Madrid, Spain, during the first wave of the pandemic: Fast spread and early dominance by D614G variantsen_US
dc.typearticleen
dc.subject.ecienciaMedicinaes_ES
dc.relation.publisherversionhttps://doi.org/10.3390/microorganisms9020454es_ES
dc.identifier.doi10.3390/microorganisms9020454es_ES
dc.identifier.publicationfirstpage454-1es_ES
dc.identifier.publicationissue2es_ES
dc.identifier.publicationlastpage454-11es_ES
dc.identifier.publicationvolume9es_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/731868./EU//VIRUSCANes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/H2020/732942./EU//FETPROACTes_ES
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.rights.ccReconocimientoes_ES
dc.rights.accessRightsopenAccessen
dc.authorUAMGarcía Rodríguez, Julio (267675)
dc.facultadUAMFacultad de Medicina
dc.institutoUAMInstituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)


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