The interplay between immune system and microbiota in inflammatory bowel disease: A narrative review
Entity
UAM. Departamento de Medicina; Instituto de Investigación Sanitaria Hospital Universitario de La Paz (IdiPAZ)Publisher
MDPI, Basel, SwitzerlandDate
2021-03-17Citation
10.3390/ijms22063076
International Journal of Molecular Sciences 22.6 (2021): 3076
ISSN
1661-6596DOI
10.3390/ijms22063076Funded by
This study was supported by Instituto de Salud Carlos III (ISCIII), Spain (grant numbers PI16/01296 and PI19/01034), by Sara Borrell contract CD19/00247 to L.A.-G. and by CIBERehdProject
Gobierno de España. PI16/01296; Gobierno de España. PI19/01034Editor's Version
https://doi.org/10.3390/ijms22063076Subjects
Crohn’s disease; Dysbiosis; Immune system; Inflammatory bowel disease; Microbiota; Ulcerative colitis; MedicinaRights
© 2021 The authorsAbstract
The importance of the gut microbiota in human health is currently well established. It contributes to many vital functions such as development of the host immune system, digestion and metabolism, barrier against pathogens or brain–gut communication. Microbial colonization occurs during infancy in parallel with maturation of the host immune system; therefore, an adequate cross‐talk between these processes is essential to generating tolerance to gut microbiota early in life, which is crucial to prevent allergic and immune‐mediated diseases. Inflammatory bowel disease (IBD) is characterized by an exacerbated immune reaction against intestinal microbiota. Changes in abundance in the gut of certain microorganisms such as bacteria, fungi, viruses, and archaea have been associated with IBD. Microbes that are commonly found in high abundance in healthy gut microbiomes, such as F. prausnitzii or R. hominis, are reduced in IBD patients. E. coli, which is usually present in a healthy gut in very low concentrations, is increased in the gut of IBD patients. Microbial taxa influence the immune system, hence affecting the inflammatory status of the host. This review examines the IBD microbiome profile and presents IBD as a model of dysbiosis.
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Google Scholar:Aldars‐García, Laila
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Marin, Alicia C.
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Chaparro Sánchez, María
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Pérez Gisbert, Francisco Javier
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