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Elucidating noncovalent reaction mechanisms: G-quartet as an intermediate in G-quadruplex assembly

dc.contributor.authorMartín-Arroyo, Miguel
dc.contributor.authordel Prado, Anselmo
dc.contributor.authorChamorro, Raquel
dc.contributor.authorBilbao, Nerea
dc.contributor.authorGonzález Rodríguez, David 
dc.contributor.otherUAM. Departamento de Químicaes_ES
dc.date.accessioned2021-10-13T07:25:35Z
dc.date.available2021-10-13T07:25:35Z
dc.date.issued2020-03-25
dc.identifier.citationAngewandte Chemie International Edition 59.23 (2020): 9041-9046en_US
dc.identifier.issn1433-7851 (print)en_US
dc.identifier.issn1521-3773 (online)en_US
dc.identifier.urihttp://hdl.handle.net/10486/698299
dc.descriptionTítulo del postprint: Elucidating noncovalent reaction mechanisms: Identification of the G-Quartet as an intermediate in G-Quadruplex assemblyen_US
dc.description.abstractIn analogy to covalent reactions, the understanding of noncovalent association pathways is fundamental to influence and control any supramolecular process. Following an approach that is reminiscent of covalent methodologies, we study here, for the first time, the mechanism of G-quadruplex formation in organic solvents. Our results support a reaction pathway in which the cation shifts the equilibrium towards a G-quartet transient intermediate, which then acts as a template in the formation of the G-quadruplex producten_US
dc.description.sponsorshipFunding from the European Research Council (ERC-Starting Grant 279548 PROGRAM-NANO) and MINECO (CTQ2014-57729-P and CTQ2017-84727-P)en_US
dc.format.extent6 pag.es_ES
dc.format.mimetypeapplication/pdfes_ES
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation.ispartofAngewandte Chemie International Editionen_US
dc.rights© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheimes_ES
dc.subject.otherG-quadruplexen_US
dc.subject.otherG-quartetsen_US
dc.subject.otherGuanine self-assemblyen_US
dc.subject.otherNoncovalent synthesisen_US
dc.subject.otherSupramolecular chemistryen_US
dc.titleElucidating noncovalent reaction mechanisms: G-quartet as an intermediate in G-quadruplex assemblyen_US
dc.typearticleen_US
dc.subject.ecienciaQuímicaes_ES
dc.date.embargoend2021-03-25
dc.relation.publisherversionhttps://doi.org/10.1002/anie.201916261es_ES
dc.identifier.doi10.1002/anie.201916261es_ES
dc.identifier.publicationfirstpage9041es_ES
dc.identifier.publicationissue23es_ES
dc.identifier.publicationlastpage9046es_ES
dc.identifier.publicationvolume59es_ES
dc.relation.projectIDGobierno de España. CTQ2014-57729-Pes_ES
dc.relation.projectIDGobierno de España. CTQ2017-84727-Pes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/279548/ERC//PROGRAM-NANOes_ES
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.rights.accessRightsopenAccesses_ES
dc.authorUAMGonzález Rodríguez, David (260340)
dc.facultadUAMFacultad de Ciencias


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