Mañana, JUEVES, 24 DE ABRIL, el sistema se apagará debido a tareas habituales de mantenimiento a partir de las 9 de la mañana. Lamentamos las molestias.
Cerebral insulin bolus revokes the changes in hepatic lipid metabolism induced by chronic central leptin infusion
Entity
UAM. Departamento de PediatríaPublisher
MDPIDate
2021-03-06Citation
10.3390/cells10030581
Cells 10.3 (2021): 581
ISSN
2073-4409DOI
10.3390/cells10030581Funded by
This research was funded by the Spanish Ministry of Science and Innovation with the help of European FEDER funding (FIS PI19/00166), Ministerio de Economía y Competitividad (BFU 2017-82565-C2-1-R) and the Network Center for Biomedical Research on Obesity and Nutrition (CIBEROBN) Instituto Carlos III. S.C. was supported by CIBEROBNProject
Gobierno de España. PI19/00166; Gobierno de España. BFU2017-82565-C2-1-REditor's Version
https://doi.org/10.3390/cells10030581Subjects
Growth hormone axis; Insulin signaling; Leptin; Lipid metabolism; Liver; MedicinaRights
© 2021 by the authorsAbstract
Central actions of leptin and insulin on hepatic lipid metabolism can be opposing and the mechanism underlying this phenomenon remains unclear. Both hormones can modulate the central somatostatinergic system that has an inhibitory effect on growth hormone (GH) expression, which plays an important role in hepatic metabolism. Using a model of chronic central leptin infusion, we evaluated whether an increase in central leptin bioavailability modifies the serum lipid pattern through changes in hepatic lipid metabolism in male rats in response to an increase in central insulin and the possible involvement of the GH axis in these effects. We found a rise in serum GH in leptin plus insulin-treated rats, due to an increase in pituitary GH mRNA levels associated with lower hypothalamic somatostatin and pituitary somatostatin receptor-2 mRNA levels. An augment in hepatic lipolysis and a reduction in serum levels of non-esterified fatty acids (NEFA) and triglycerides were found in leptin-treated rats. These rats experienced a rise in lipogenic-related factors and normalization of serum levels of NEFA and triglycerides after insulin treatment. These results suggest that an increase in insulin in leptin-treated rats can act on the hepatic lipid metabolism through activation of the GH axis
Files in this item
Google Scholar:Barrios, Vicente
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López-Villar, Elena
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Frago Fernández, Laura María
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Canelles, Sandra
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Díaz-González, Francisca
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Burgos-Ramos, Emma
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Frühbeck, Gema
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Chowen, Julie A.
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Argente Oliver, Jesús
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