Anti-inflammatory and anti-arthritic activities of glycosylated flavonoids from syzygium jambos in edematogenic agent-induced paw edema in mice
Entity
UAM. Departamento de Química OrgánicaPublisher
SpringerDate
2021-08-23Citation
10.1007/s43450-021-00167-0
Revista Brasileira de Farmacognosia 31 (2021): 429-441
ISSN
1981-528XDOI
10.1007/s43450-021-00167-0Funded by
This work was supported by the National Herbarium of Bolivia and the Fundación de la Universidad Autónoma de Madrid (FUAM)Editor's Version
https://doi.org/10.1007/s43450-021-00167-0Subjects
Inflammation; NF-κB; Polyphenols; Rose apple; TNF-α; QuímicaRights
© The Authors 2021Abstract
Two glycosylated flavonoids, the quercetin-3-O-β-D-xylofuranosyl-(1 → 2)-α-l-rhamnopyranoside and myricetin-3-O-β-d-xylofuranosyl-(1 → 2)-α-l-rhamnopyranoside, were isolated from the CH2Cl2/MeOH fraction of Syzygium jambos (L.) Alston, Myrtaceae. The structures of these compounds were elucidated by spectroscopic means. The cytotoxicity of the compounds was evaluated against the RAW 264.7 cell lines by the lactate dehydrogenase assay. All analyzed compounds were less cytotoxic than the positive control (actinomycin D, CC50 = 0.008 μM). The anti-inflammatory and anti-arthritic activities were evaluated by measuring inflammatory parameters in murine models. The two glycosylated flavonoids inhibited the production of tumor necrosis factor-α in RAW 264.7 cell line with IC50 of 1.68 and 1.11 μM, respectively. In addition, all flavonoids decreased the levels of tumor necrosis factor-α, C-reactive protein, and fibrinogen at a dose of 5 mg/kg in murine models
Files in this item
Google Scholar:Apaza Ticona, Luis
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Souto Pérez, Beatriz
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Martín Alejano, Vanesa
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Slowing, Karla
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