Metal-free visible light-promoted synthesis of isothiazoles: a catalytic approach for N-S bond formation from iminyl radicals under batch and flow conditions
Entity
UAM. Departamento de Química OrgánicaPublisher
Royal Society of ChemistryDate
2020-09-25Citation
10.1039/d0gc02618b
Green Chemistry 22 (2020): 6792-6797
ISSN
1463-9262 (print); 1463-9270 (online)DOI
10.1039/d0gc02618bFunded by
We acknowledge the financial support by the Spanish Government (RTI2018-095038-B-I00) and ERC (ERC-CG, 647550)Project
Gobierno de España. RTI2018-095038-B-I00; info:eu-repo/grantAgreement/EC/H2020/647550/EU//UNBICATEditor's Version
https://doi.org/10.1039/d0gc02618bSubjects
Isothiazoles; Iminyl radicals; Photoredox; QuímicaRights
© 2020 The Royal Society of ChemistryAbstract
A sustainable synthesis of isothiazoles has been developed using an α-amino-oxy acid auxiliary and applying photoredox catalysis. This simple strategy features mild conditions, broad scope and wide functional group tolerance representing a new enviromentally friendly option to prepare these highly valuable heterocycles. Furthermore, the synthetic value of the method is highlighted by the preparation of a natural product derivative and the implementation of the reaction in a continuous flow setup
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Google Scholar:Cabrera-Afonso, María Jesús
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Cembellín, Sara
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Halima-Salem, Adnane
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Berton, Mateo
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Marzo, Leyre
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Miloudi, Abdellah
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Maestro Rubio, Carmen
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Alemán Lara, José Julián
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