Tuning the nanoaggregates of sialylated biohybrid photosensitizers for intracellular activation of the photodynamic response
Entity
UAM. Departamento de Biología; UAM. Departamento de Química OrgánicaPublisher
WileyDate
2021-07-02Citation
10.1002/chem.202100681
Chemistry - A European Journal 27.37 (2021): 9634-9642
ISSN
0947-6539 (print); 1521-3765 (online)DOI
10.1002/chem.202100681Funded by
TThis work was supported by EU (CosmoPHOS-nano, EU-FP7-NMP-2012-LARGE-6, 310337), MINECO-Feder funds (CTQ2017-85393-P (T.T.), CTQ-2014-53673-P and CTQ-2017-89539-P(A.d.l.E.), Instituto de Salud Carlos III; PI18/00708 (A.J.), andPCIN-2017-042/EuroNanoMed2017-191, TEMPEAT (T.T.)), andComunidad Autonoma de Madrid (FOTOCARBON, S2013/MIT 2841). DLS measurements were carried out by VAM with aNanotrac Wave analyzer, during an internship in the MESA+Institute for Nanotechnology of the University of Twente.IMDEA Nanociencia also acknowledges support from the“Severo Ochoa” Programme for Centres of Excellence in R&D(MINECO, grant SEV-2016-0686)Project
info:eu-repo/grantAgreement/EC/FP7/310337/EU//COSMOPHOS-NANO; Gobierno de España. CTQ2017-85393-P; Gobierno de España. CTQ-2014-53673-P; Gobierno de España. CTQ-2017-89539-P; Gobierno de España. PCIN-2017-042; Gobierno de España. SEV-2016-0686; Comunidad de Madrid. S2013/MIT 2841/FOTOCARBONEditor's Version
https://doi.org/10.1002/chem.202100681Subjects
Biohybrids; Nanoaggregates; Photosensitizers; Phthalocyanine; Self-assembly; QuímicaRights
© 2021 The AuthorsAbstract
In the endeavor of extending the clinical use of photodynamic therapy (PDT) for the treatment of superficial cancers and other neoplastic diseases, deeper knowledge and control of the subcellular processes that determine the response of photosensitizers (PS) are needed. Recent strategies in this direction involve the use of activatable and nanostructured PS. Here, both capacities have been tuned in two dendritic zinc(II) phthalocyanine (ZnPc) derivatives, either asymmetrically or symmetrically substituted with 3 and 12 copies of the carbohydrate sialic acid (SA), respectively. Interestingly, the amphiphilic ZnPc-SA biohybrid (1) self-assembles into well-defined nanoaggregates in aqueous solution, facilitating cellular internalization and transport whereas the PS remains inactive. Within the cells, these nanostructured hybrids localize in the lysosomes, as usually happens for anionic and hydrophilic aggregated PS. Yet, in contrast to most of them (e. g., compound 2), hybrid 1 recovers the capacity for photoinduced ROS generation within the target organelles due to its amphiphilic character; this allows disruption of aggregation when the compound is inserted into the lysosomal membrane, with the concomitant highly efficient PDT response
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Google Scholar:Almeida-Marrero, Verónica
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Mascaraque Checa, Marta
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Jesús Vicente-Arana, María
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Juarranz de la Fuente, Ángeles
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Torres Cebada, Tomás
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de la Escosura, Andrés
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