UAM_Biblioteca

View Item 

Metal-free solvent promoted oxidation of benzylic secondary amines to nitrones with H202

Author
Granato, Álisson Silva; Amarante, Giovanni Wilson; Adrio Sevilla, Francisco Javieruntranslated
Entity
UAM. Departamento de Química Orgánica
Publisher
American Chemical Society
Date
2021-09-16
Citation
Journal of Organic Chemistry (JOC) 86.19 (2021): 13817-13823
ISSN
0022-3263 (print); 1520-6904 (online)
DOI
10.1021/acs.joc.1c01888
Funded by
We thank FEDER/Ministerio de Ciencia, Innovación y Universidades−Agencia Estatal de Investigación (Grant PGC2018-098660-B-I00) and CAPES (Finance Code 001), CNPq (310514/2018-5), FAPEMIG for financial support
Project
Gobierno de España. PGC2018-098660-B-I00
Editor's Version
https://doi.org/10.1021/acs.joc.1c01888
Subjects
Nitrones; Metal-free; Benzylic; Amines; H2O2; Química
URI
http://hdl.handle.net/10486/700526
Rights
© 2021 American Chemical Society

Licencia Creative Commons
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.

Abstract

An environmentally benign protocol for the generation of nitrones from benzylic secondary amines via catalyst-free oxidation of secondary amines using H2O2 in MeOH or CH3CN is described. This methodology provides a selective access to a variety of C-aryl nitrones in yields of 60 to 93%. Several studies have been performed to shed light on the reaction mechanism and the role of the solvent
Show full item record

Files in this item

Thumbnail
Size
1.177Mb
Format
PDF

Google™ Scholar:Granato, Álisson Silva - Amarante, Giovanni Wilson - Adrio Sevilla, Francisco Javier

This item appears in the following Collection(s)