Regioselective monoborylation of spirocyclobutenes
Entity
UAM. Departamento de Química OrgánicaPublisher
American Chemical SocietyDate
2021-09-15Citation
10.1021/acs.orglett.1c02645
Organic Letters 23.19 (2021): 7434−7438
ISSN
1523-7060 (print); 1523-7052 (online)DOI
10.1021/acs.orglett.1c02645Funded by
We thank the European Research Council (ERC-337776) and MINECO and MICIIN (CTQ2016-78779-R and PID2019-107380GB-I00 to M.T.; PID2019106184GB-I00 and RED2018-102387-T to I.F.) for financial support. L.N. thanks Comunidad de Madrid for a predoctoral fellowship. We acknowledge Dr. Josefina Perles (UAM) for X-ray structure análisisProject
Info:eu-repo/grantAgreement/EC/FP7/337776/EU//DAUBOR; Gobierno de España. CTQ2016-78779-R; Gobierno de España. PID2019-107380GB-I00; Gobierno de España. PID2019-106184GB-I00Editor's Version
http://doi.org/10.1021/acs.orglett.1c02645Subjects
Spirocyclic; Cyclobutanes; Spirocyclobutenes; QuímicaRights
© 2021 American Chemical SocietyAbstract
We present a strategy for the synthesis of spirocyclic cyclobutanes with modulable exit vectors based on the regioselective monoborylation of spirocyclobutenes. Using an inexpensive copper salt and a commercially available bidentate phosphine, a broad variety of borylated spirocycles have been prepared with complete regiocontrol. The boryl moiety provides a synthetic handled for further functionalization, allowing access to a wide array of spirocyclic building blocks from a common intermediate
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Google Scholar:Nóvoa, Luis
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Trulli, Laura
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Fernández, Israel
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Parra, Alejandro
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Tortosa Manzanares, Mariola
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