Nanoporous silicon microparticles embedded into oxidized hyaluronic acid/adipic acid dihydrazide hydrogel for enhanced controlled drug delivery
EntityUAM. Departamento de Física Aplicada
10.1016/j.micromeso.2020.110634Microporous and Mesoporous Materials 310 (2021): 110634
Funded byThis work was financially supported by FONDECYT–Chile (grant number 11180395), CONICYT PFCHA/DOCTORADO/2017-21172001 (Nelson Naveas) and CNPq 140924/2017-5 (Carla França). We thank Fig. 8. A) Cytotoxicity of nPSi microparticles. B) Cell viability of hydrogels. C.G. Franca ̧ et al. Microporous and Mesoporous Materials 310 (2021) 110634 11 Dr. Héctor Pesenti for providing the DRX facility (FONDEQUIP–Chile, project 160152), and Dr. Luis Sanhueza for optical measurements of UVVis spectroscopy
SubjectsAdipic acid dihydrazide; Drug delivery; Hydrogel; Mechanical resistance; Nanoporous silicon; Oxidized hyaluronic acid; Física
Rights© 2020 Elsevier Inc.
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial-SinObraDerivada 4.0 Internacional.
Oxidized hyaluronic acid cross-linked with adipic acid dihydrazide (oxi-HA/ADH) forms an injectable and biocompatible hydrogel suitable for treatment of musculoskeletal diseases and for drug delivery applications. In that sense, nanoporous silicon (nPSi) can be combined with biopolymers, such as oxi-HA/ADH hydrogel, to display new characteristics, which are not exhibited by the individual constituents alone. Under this context, in this work nPSi microparticles at concentrations from 0.1% to 1% m/v were embedded into oxi-HA/ADH hydrogel to improve its mechanical stability and enhance its control over drug release kinetics using Rose Bengal (RB) as a model drug because its cytotoxic effect in different cancer cell lines and tumors has been previously reported. Our results showed, for both compressive force and stress strength tests, that oxi-HA/ADH hydrogel with 1% nPSi microparticles doubled the values of control samples. Moreover, samples of oxi-HA/ADH with nPSi microparticles improved RB release kinetics control over pure oxi-HA/ADH hydrogel. Finally, the cell viability of nPSi microparticles embedded into oxi-HA/ADH hydrogel was confirmed using fibroblasts
Google Scholar:França, Carla Giometti - Plaza, Tanya - Naveas, Nelson - Andrade Santana, Maria Helena - Manso Silván, Miguel - Recio, Gonzalo - Hernández-Montelongo, Jacobo
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