Reliable and remote monitoring of absolute temperature during liver inflammation via luminescence-lifetime-based nanothermometry
EntityUAM. Departamento de Física de Materiales
10.1002/adma.202107764Advanced Materials 34 (2022): 2107764
ISSN0935-9648 (print); 1521-4095 (online)
Funded byY.S. J.L., and I.Z.-G. contributed equally to this work. This work was supported by the Spanish Ministerio de Ciencia under project PID2019-106211RB-I00 and Ministerio de Economía y Competitividad under project MAT2017-83111R, by the Comunidad Autónoma de Madrid (B2017/BMD-3867 RENIM-CM), and co-financed by the European Structural and Investment fund. Additional funding was provided by the European Union’s Horizon 2020 FET Open program (Grant Agreement No. 801305, NanoTBTech), and also by COST action CA17140. Y.S. acknowledges a scholarship from the China Scholarship Council (No. 201806870023). I.Z.-G. thanks UCM-Santander for a predoctoral contract (CT63/19-CT64/19). M.F was funded by a research contract from the Community of Madrid (PEJ-2018-AI/SAL-11315). E.X. is grateful for a Juan de la Cierva Formación scholarship (FJC2018-036734-I). J.L. is grateful for FPI scholarship PID2019-106211RB-100. A. B. acknowledges funding from Comunidad de Madrid through TALENTO grant ref. 2019-T1/IND-14014
ProjectGobierno de España. PID2019-106211RB-I00; Gobierno de España. MAT2017-83111-R; info:eu-repo/grantAgreement/EC/H2020/801305/EU//NanoTBTech; Comunidad de Madrid. B2017/BMD-3867/RENIM-CM
SubjectsHigh thermal sensitivity; Inflammation; Nanothermometry; Organ-temperature monitoring; Temperature-dependent fluorescence lifetime; Física
Rights© 2022 The Authors
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.
Temperature of tissues and organs is one of the first parameters affected by physiological and pathological processes, such as metabolic activity, acute trauma, or infection-induced inflammation. Therefore, the onset and development of these processes can be detected by monitoring deviations from basal temperature. To accomplish this, minimally invasive, reliable, and accurate measurement of the absolute temperature of internal organs is required. Luminescence nanothermometry is the ideal technology for meeting these requirements. Although this technique has lately undergone remarkable developments, its reliability is being questioned due to spectral distortions caused by biological tissues. In this work, how the use of bright Ag2S nanoparticles featuring temperature-dependent fluorescence lifetime enables reliable and accurate measurement of the absolute temperature of the liver in mice subjected to lipopolysaccharide-induced inflammation is demonstrated. Beyond the remarkable thermal sensitivity (≈ 3% °C–1 around 37 °C) and thermal resolution obtained (smaller than 0.3 °C), the results included in this work set a blueprint for the development of new diagnostic procedures based on the use of intracorporeal temperature as a physiological indicator
Google Scholar:Shen, Yingli - Lifante, José - Zabala-Gutierrez, Irene - de la Fuente-Fernández, María - Granado, Miriam - Fernández, Nuria - Rubio-Retama, Jorge - Jaque, Daniel - Marin, Riccardo - Ximendes, Erving - Benayas, Antonio
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