Dietary fat intake and risk of disabling hearing impairment: a prospective population-based cohort study
EntityUAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología
10.1007/s00394-021-02644-7European Journal of Nutrition (2021): 1-12
Funded byUK Biobank was established by the Wellcome Trust medical charity, Medical Research Council, Department of Health, Scottish Government and the Northwest Regional Development Agency. It has also had funding from the Welsh Government, British Heart Foundation, Cancer Research UK, and Diabetes UK. This work was supported by FIS grants 19/319 and 20/1040, (Instituto de Salud Carlos III, State Secretary of R + D + I and FEDER/FSE)
ProjectGobierno de España. FIS19/319; Gobierno de España. FIS20/1040
SubjectsCohort study; Dietary fat intake; Hearing function; UK Biobank; Medicina
Rights© 2021 by the authors
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Purpose: To examine the associations of specific dietary fats with the risk of disabling hearing impairment in the UK Biobank study. Methods: This cohort study investigated 105,592 participants (47,308 men and 58,284 women) aged ≥ 40 years. Participants completed a minimum of one valid 24-h recall (Oxford Web-Q). Dietary intake of total fatty acids, polyunsaturated fatty acids (PUFA), saturated fatty acids (SFA), and monounsaturated fatty acids (MUFA) was assessed at baseline. Functional auditory capacity was measured with a digit triplet test (DTT), and disabling hearing impairment was defined as a speech reception threshold in noise > − 3.5 dB in any physical exam performed during the follow-up. Results: Over a median follow-up of 3.2 (SD: 2.1) years, 832 men and 872 women developed disabling hearing impairment. After adjustment for potential confounders, including lifestyles, exposure to high-intensity sounds, ototoxic medication and comorbidity, the hazard ratios (HRs), and 95% confidence interval (CI) of disabling hearing function, comparing extreme quintiles of intakes were 0.91 (0.71–1.17) for total fat, 1.09 (0.83–1.44) for PUFA, 0.85 (0.64–1.13) for SFA and 1.01 (0.74–1.36) for MUFA among men. Among women, HRs comparing extreme intakes were 0.98 (0.78–1.24) for total fat, 0.69 (0.53–0.91) for PUFA, 1.26 (0.96–1.65) for SFA, and 0.91 (0.68–1.23) for MUFA. Replacing 5% of energy intake from SFA with an equivalent energy from PUFA was associated with 25% risk reduction (HR: 0.75; 95% CI: 0.74–0.77) among women. Conclusions: PUFA intake was associated with decreased risk of disabling hearing function in women, but not in men
Google Scholar:Yévenes-Briones, Humberto - Caballero Díaz, Francisco Félix - Struijk, Ellen A. - Lana, Alberto - Rodríguez Artalejo, Fernando - López García, Esther
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