Finding answers in lipid profile in COVID-19 patients
EntityUAM. Departamento de Medicina
10.1007/s12020-021-02881-0Endocrine 74.3 (2021): 443–454
Funded byThis work was supported by the following grants: Proyectos de Investigación en Salud (FIS) PI16-02091 and PI19-00584 (funded by Instituto de Salud Carlos III), TIRONET2-CM, B2017/BMD-3724 (funded by Comunidad de Madrid) and cofinanced by FEDER funds to M.M.
ProjectGobierno de España. PI16-02091; Gobierno de España. PI19-00584; Comunidad de Madrid. B2017/BMD-3724/TIRONET2-CM
Subjectsbiomarker; COVID-19; Lipid profile; prognosis; Medicina
Rights© The Author(s) 2021
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Introduction: A small percentage of patients will develop a severe form of COVID-19 caused by SARS-CoV-2 infection. Thus, it is important to predict the potential outcomes identifying early markers of poor prognosis. In this context, we evaluated the association of SARS-CoV-2 infection with lipid abnormalities and their role in prognosis. Methods: Single-center, retrospective, observational study of COVID-19 patients admitted from March to October 2020. Clinical and laboratory data, comorbidities, and treatments for COVID-19 were evaluated. Main outcomes including intensive care unit (ICU) admission and mortality were analyzed with a multivariable Cox proportional hazards regression model. Results: We selected 1489 from a total of 2038 consecutive patients with confirmed COVID-19, who had a complete lipid profile before ICU admission. During the follow-up performed in 1109 patients, we observed a decrease in T-c, HDL-c, and LDL-c in 28.6%, 42.9%, and 30.4% of patients, respectively, and an increase in TG in 76.8%. The decrease of both T-c and HDL- c was correlated with a decrease in albumin levels (r = 0.39 and r = 0.37, respectively). Kaplan–Meier survival curves found an increased ICU admission in patients with lower T-c (HR 0.55, CI 0.36–0.86), HDL-c (HR 0.61, CI 0.45–0.84), and LDL-c (HR 0.85, CI 0.74–0.97). Higher values of T-c (HR 0.45, CI 0.36–0.57), HDL-c (HR 0.66, CI 0.54–0.81), and LDL-c (HR 0.86, CI 0.78–0.94) showed a protective effect on mortality. Conclusions: Abnormalities in lipid profile are a frequent complication of SARS-CoV-2 infection and might be related to morbidity and mortality
Google Scholar:Sampedro-Nuñez, M. - Aguirre-Moreno, N. - García-Fraile Fraile, L. - Jiménez-Blanco, S. - Knott-Torcal, C. - Sanz-Martin, P. - Fernández-Jiménez, G. - Marazuela Azpiroz, Mónica
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