A callosal biomarker of behavioral intervention outcomes for autism spectrum disorder? A case-control feasibility study with diffusion tensor imaging
EntityUAM. Departamento de Psicología Biológica y de la Salud
PublisherPublic Library of Science
10.1371/journal.pone.0262563PLoS ONE 17.2 (2022): e0262563
Funded byThis study was supported by grants from Oakley Mental Health Foundation (project no. 3705925), The University of Auckland (Marsden Fund Near Miss Support Program), and through a research contract between ABA España and The University of Auckland (project no. CON02739); all awarded to JVO
Subjectsneural biomarkers of a behavioral intervention; autism spectrum disorder (ASD); Psicología
Rights© 2022 Virues-Ortega et al.
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Tentative results from feasibility analyses are critical for planning future randomized control trials (RCTs) in the emerging field of neural biomarkers of behavioral interventions. The cur rent feasibility study used MRI-derived diffusion imaging data to investigate whether it would be possible to identify neural biomarkers of a behavioral intervention among people diag nosed with autism spectrum disorder (ASD). The corpus callosum has been linked to cogni tive processing and callosal abnormalities have been previously found in people diagnosed with ASD. We used a case-control design to evaluate the association between the type of intervention people diagnosed with ASD had previously received and their current white matter integrity in the corpus callosum. Twenty-six children and adolescents with ASD, with and without a history of parent-managed behavioral intervention, underwent an MRI scan with a diffusion data acquisition sequence. We conducted tract-based spatial statistics and a region of interest analysis. The fractional anisotropy values (believed to indicate white mat ter integrity) in the posterior corpus callosum was significantly different across cases (exposed to parent-managed behavioral intervention) and controls (not exposed to parent managed behavioral intervention). The effect was modulated by the intensity of the behav ioral intervention according to a dose-response relationship. The current feasibility case control study provides the basis for estimating the statistical power required for future RCTs in this field. In addition, the study demonstrated the effectiveness of purposely-developed motion control protocols and helped to identify regions of interest candidates. Potential clini cal applications of diffusion tensor imaging in the evaluation of treatment outcomes in ASD are discussed
Google Scholar:Virues-Ortega, Javier - McKay, Nicole S. - McCormack, Jessica C. - Lopez, Nerea - Liu, Rosalie - Kirk, Ian
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