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The impact of COVID-19 on patients with asthma

Author
Izquierdo, José Luis; Almonacid, Carlos; González, Yolanda; Del Rio-Bermudez, Carlos; Ancochea Bermúdez, Juliountranslated; Cárdenas, Remedios; Lumbreras, Sara; Soriano, Joan B.
Entity
UAM. Departamento de Medicina
Publisher
European Respiratory Society
Date
2021-03-01
Citation
10.1183/13993003.03142-2020
European Respiratory Journal 57.3 (2021): 2003142
 
 
 
ISSN
0903-1936
DOI
10.1183/13993003.03142-2020
Funded by
Grant COVID-19 UAH 2019/00003/016/001/005 from the University of Alcalá (Spain)
Editor's Version
http://doi.org/ 10.1183/13993003.03142-2020
Subjects
COVID-19; asthma; Medicina
URI
http://hdl.handle.net/10486/701225
Rights
© ERS 2021

Licencia de Creative Commons
Esta obra está bajo una licencia de Creative Commons Reconocimiento-NoComercial 4.0 Internacional.

Abstract

Background: An association between the severity of coronavirus disease 2019 (COVID-19) and the presence of certain chronic conditions has been suggested. However, unlike influenza and other viruses, the disease burden of COVID-19 in patients with asthma has been less evident. Objective: To understand the impact of COVID-19 in patients with asthma. Methods: Using big-data analytics and artificial intelligence through the SAVANA Manager clinical platform, we analysed clinical data from patients with asthma from January 1 to May 10, 2020. Results: Out of 71182 patients with asthma, 1006 (1.41%) suffered from COVID-19. Compared to asthmatic individuals without COVID-19, patients with asthma and COVID-19 were significantly older (55 versus 42 years), predominantly female (66% versus 59%), smoked more frequently and had higher prevalence of hypertension, dyslipidaemias, diabetes and obesity. Allergy-related factors such as rhinitis and eczema were less common in asthmatic patients with COVID-19 (p<0.001). In addition, higher prevalence of these comorbidities was observed in patients with COVID-19 who required hospital admission. The use of inhaled corticosteroids (ICS) was lower in patients who required hospitalisation due to COVID-19, as compared to non-hospitalised patients (48.3% versus 61.5%; OR 0.58, 95% CI 0.44-0.77). Although patients treated with biologics (n=865; 1.21%) showed increased severity and more comorbidities at the ear, nose and throat level, COVID-19-related hospitalisations in these patients were relatively low (0.23%). Conclusion: Patients with asthma and COVID-19 were older and at increased risk due to comorbidity-related factors. ICS and biologics are generally safe and may be associated with a protective effect against severe COVID-19 infection
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Google™ Scholar:Izquierdo, José Luis - Almonacid, Carlos - González, Yolanda - Del Rio-Bermudez, Carlos - Ancochea Bermúdez, Julio - Cárdenas, Remedios - Lumbreras, Sara - Soriano, Joan B.

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  • Producción científica en acceso abierto de la UAM [18127]

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