The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
EntityUAM. Departamento de Medicina Preventiva y Salud Pública y Microbiología
10.1007/s00394-022-02823-0European Journal of Nutrition (2022): 1-13
ISSN1436-6207 (print); 1436-6215 (online)
Funded byOpen Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was also supported in part by CIBERCV, CIBERESP and Grants: PIE16 / 00022, PI17/1709, PI19/00948, PI20/144 from the Instituto de Salud Carlos III (co-supported by the European Regional Development Fund ‘Investing in your future’). CD-V has a Talent Attraction Contract (“Contrato Atracción de Talento”) from the Regional Government of the Madrid Community/IMDEA Food
ProjectGobierno de España. PIE16/00022; Gobierno de España. PI17/1709; Gobierno de España. PI19/00948; Gobierno de España. PI20/00144
SubjectsCoronary calcium; Cross-sectional cohort study; Flavonoids; Red wine; Stilbenes; Subclinical coronary atherosclerosis; Medicina
Rights© The Author(s) 2022
Esta obra está bajo una Licencia Creative Commons Atribución 4.0 Internacional.
Purpose: It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects. Methods: Ultrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between 2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium. Results: A higher intake of flavonoids (third vs. first tertile) was associated with a lower risk of both carotid (OR 0.80: CI 95% 0.62–1.02; P trend 0.094) and femoral (0.62: 0.48–0.80, P trend < 0.001) subclinical atherosclerosis. A higher intake of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46–0.83; P trend 0.009) and positive coronary calcium (0.75: 0.55–1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk of positive coronary calcium (0.80: 0.62–1.03; P trend 0.111). The associations remained similar when adjusted for blood lipids and blood pressure. Conclusion: Dietary flavonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated with lower prevalence of subclinical atherosclerosis in middle-aged subjects.
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Google Scholar:Montero Salazar, Henry - de Deus Mendonça, Raquel - Laclaustra, Martín - Moreno Franco, Belén - Åkesson, Agneta - Guallar Castillón, María Pilar - Donat Vargas, Carolina
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Donat-Vargas, Carolina; Sandoval-Insausti, Helena; Peñalvo, José L.; Moreno Iribas, Maria Concepción; Amiano, Pilar; Bes-Rastrollo, Maira; Molina-Montes, Esther; Moreno-Franco, Belén; Agudo, Antonio; Mayo, Cristina Lasheras; Laclaustra, Martín; De La Fuente Arrillaga, Carmen; Chirlaque Lopez, Maria Dolores; Sánchez, Maria José; Martínez-Gonzalez, Miguel Angel; Pilar, Guallar Castillón