The intake of flavonoids, stilbenes, and tyrosols, mainly consumed through red wine and virgin olive oil, is associated with lower carotid and femoral subclinical atherosclerosis and coronary calcium
Entity
UAM. Departamento de Medicina Preventiva y Salud Pública y MicrobiologíaPublisher
SpringerDate
2022-03-07Citation
10.1007/s00394-022-02823-0
European Journal of Nutrition (2022): 1-13
ISSN
1436-6207 (print); 1436-6215 (online)DOI
10.1007/s00394-022-02823-0Funded by
Open Access funding provided thanks to the CRUE-CSIC agreement with Springer Nature. This study was also supported in part by CIBERCV, CIBERESP and Grants: PIE16 / 00022, PI17/1709, PI19/00948, PI20/144 from the Instituto de Salud Carlos III (co-supported by the European Regional Development Fund ‘Investing in your future’). CD-V has a Talent Attraction Contract (“Contrato Atracción de Talento”) from the Regional Government of the Madrid Community/IMDEA FoodProject
Gobierno de España. PIE16/00022; Gobierno de España. PI17/1709; Gobierno de España. PI19/00948; Gobierno de España. PI20/00144Editor's Version
https://doi.org/10.1007/s00394-022-02823-0Subjects
Coronary calcium; Cross-sectional cohort study; Flavonoids; Red wine; Stilbenes; Subclinical coronary atherosclerosis; MedicinaRights
© The Author(s) 2022Abstract
Purpose: It is suggested that polyphenols back the cardiovascular protection offered by the Mediterranean diet. This study evaluates the association of specific types of dietary polyphenols with prevalent subclinical atherosclerosis in middle-aged subjects. Methods: Ultrasonography and TC were performed on 2318 men from the Aragon Workers Health Study, recruited between 2011 and 2014, to assess the presence of plaques in carotid and femoral arteries and coronary calcium. Polyphenol intake was assessed using a validated semi-quantitative 136-item food frequency questionnaire. The Phenol Explorer database was used to derive polyphenol class intake. Logistic and linear regressions were used to estimate the cross-sectional association of polyphenols intake with femoral and carotid subclinical atherosclerosis and coronary calcium. Results: A higher intake of flavonoids (third vs. first tertile) was associated with a lower risk of both carotid (OR 0.80: CI 95% 0.62–1.02; P trend 0.094) and femoral (0.62: 0.48–0.80, P trend < 0.001) subclinical atherosclerosis. A higher intake of stilbenes was associated with a lower risk of femoral subclinical atherosclerosis (0.62: 0.46–0.83; P trend 0.009) and positive coronary calcium (0.75: 0.55–1.03; P trend 0.131). A higher intake of tyrosols was also associated with a lower risk of positive coronary calcium (0.80: 0.62–1.03; P trend 0.111). The associations remained similar when adjusted for blood lipids and blood pressure. Conclusion: Dietary flavonoids, stilbenes, and tyrosols, whose main sources are red wine and virgin olive oil, are associated with lower prevalence of subclinical atherosclerosis in middle-aged subjects.
Files in this item
Google Scholar:Montero Salazar, Henry
-
de Deus Mendonça, Raquel
-
Laclaustra, Martín
-
Moreno Franco, Belén
-
Åkesson, Agneta
-
Guallar Castillón, María Pilar
-
Donat Vargas, Carolina
This item appears in the following Collection(s)
Related items
Showing items related by title, author, creator and subject.
-
Olive oil consumption is associated with a lower risk of cardiovascular disease and stroke
Donat-Vargas, Carolina; Sandoval-Insausti, Helena; Peñalvo, José L.; Moreno Iribas, Maria Concepción; Amiano, Pilar; Bes-Rastrollo, Maira; Molina-Montes, Esther; Moreno-Franco, Belén; Agudo, Antonio; Mayo, Cristina Lasheras; Laclaustra, Martín; De La Fuente Arrillaga, Carmen; Chirlaque Lopez, Maria Dolores; Sánchez, Maria José; Martínez-Gonzalez, Miguel Angel; Pilar, Guallar Castillón
2021-12-03